Propagations of spontaneous brain activity in awake rats

Yikang Liu, Nanyin Zhang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Slow propagations of spontaneous brain activity have been reported in multiple species. However, systematical investigation of the organization of such brain activity is still lacking. In this study, we analyzed propagations of spontaneous brain activity using a reference library of characteristic resting-state functional connectivity (RSFC) patterns in awake rodents. We found that transitions through multiple distinct RSFC patterns were reproducible not only in transition sequences but also in transition time delays. In addition, the organization of these transitions and their spatiotemporal dynamic patterns were revealed using a graphical model. We further identified prominent brain regions involved in these transitions. These results provide a comprehensive framework of brainwide propagations of spontaneous activity in awake rats. This study also offers a new tool to study the spatiotemporal dynamics of activity in the resting brain.

Original languageEnglish (US)
Article number116176
StatePublished - Nov 15 2019

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience


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