Prophylactic cranial irradiation for patients with small cell lung cancer: An enduring controversy

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Small cell lung cancer (SCLC) is a systemic disease that usually presents with locally bulky disease in the lung and mediastinal nodes, with either subclinical (limited stage) or detectable (extensive stage) extrathoracic metastases. Treatment with local modalities alone leads almost invariably to systemic relapse, and treatment with only systemic therapy usually results in recurrence at sites of initially demonstrated disease. Although prophylactic cranial radiation is far from an ideal solution to the problem of CNS metastases in patients with SCLC, it presently seems preferable to the alternative of observation and generally ineffective palliative treatment at time of relapse in the CNS.

Original languageEnglish (US)
Pages (from-to)151-166
Number of pages16
JournalChest Surgery Clinics of North America
Volume7
Issue number1
StatePublished - Jan 22 1997

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Cranial Irradiation
Small Cell Lung Carcinoma
Recurrence
Mediastinal Diseases
Neoplasm Metastasis
Palliative Care
Lung Diseases
Therapeutics
Observation
Radiation

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

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abstract = "Small cell lung cancer (SCLC) is a systemic disease that usually presents with locally bulky disease in the lung and mediastinal nodes, with either subclinical (limited stage) or detectable (extensive stage) extrathoracic metastases. Treatment with local modalities alone leads almost invariably to systemic relapse, and treatment with only systemic therapy usually results in recurrence at sites of initially demonstrated disease. Although prophylactic cranial radiation is far from an ideal solution to the problem of CNS metastases in patients with SCLC, it presently seems preferable to the alternative of observation and generally ineffective palliative treatment at time of relapse in the CNS.",
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Prophylactic cranial irradiation for patients with small cell lung cancer : An enduring controversy. / Wagner Jr., Henry.

In: Chest Surgery Clinics of North America, Vol. 7, No. 1, 22.01.1997, p. 151-166.

Research output: Contribution to journalReview article

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AB - Small cell lung cancer (SCLC) is a systemic disease that usually presents with locally bulky disease in the lung and mediastinal nodes, with either subclinical (limited stage) or detectable (extensive stage) extrathoracic metastases. Treatment with local modalities alone leads almost invariably to systemic relapse, and treatment with only systemic therapy usually results in recurrence at sites of initially demonstrated disease. Although prophylactic cranial radiation is far from an ideal solution to the problem of CNS metastases in patients with SCLC, it presently seems preferable to the alternative of observation and generally ineffective palliative treatment at time of relapse in the CNS.

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