Purpose: To report a case of Propionibacterium acnes endophthalmitis in a patient with a Baerveldt glaucoma implant. Patient and Method: An 8-year-old boy presented with left eye pain, extreme photophobia, and acute anterior uveitis > 6 months after Baerveldt glaucoma implantation. A diagnosis of P. acnes endophthalmitis was made after positive culture of the explanted Baerveldt device. Results: Initially, the patient was treated with intravitreal vancomycin and ceftazidime which led to mild early clinical improvement followed by deterioration of findings with recurrence of fibrin at the Baerveldt tube ostium within the anterior chamber. Repeat intravitreal injections were given to include antifungal coverage, along with intracameral moxifloxacin and subconjunctival vancomycin around the Baerveldt reservoir. Symptoms and findings again recurred, ultimately leading to the decision for complete removal of the glaucoma implant along with irrigation of the scleral bed with moxifloxacin. P. acnes was cultured from the extracted implant. The endophthalmitis resolved completely after implant removal. Conclusions: Despite introduction of antibiotics into the intravitreal, intracameral, and subconjunctival space surrounding the Baerveldt implant, infection persisted until complete explantation of the device. Early explantation should be considered in glaucoma drainage device endophthamitis secondary to P. acnes.
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