Propranolol in the treatment of narcolepsy

A. Kales, C. R. Soldatos, R. Cadieux, E. O. Bixler, T. L. Tan, M. B. Scharf

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Serotoninergic systems are thought to be involved in production of slow-wave sleep and priming mechanisms that initiate REM sleep, whereas a dysfunction of both non-REM and REM sleep has been identified in narcolepsy with cataplexy. More recently, propranolol was shown to be an antagonist of serotonin's activity in the central nervous system, a property apparently related to a serotonin-receptor blocking effect similar in magnitude to that of methysergide. Our hypothesis that the effect of propranolol on narcolepsy is a function of its serotonin-blocking properties is supported by the reported effectiveness of methysergide in treating narcolepsy; methysergide clearly ameliorated sleep attacks, like propranolol in our study, whereas its effects on cataplexy varied.

Original languageEnglish (US)
Pages (from-to)741-743
Number of pages3
JournalAnnals of internal medicine
Volume91
Issue number5
DOIs
StatePublished - Jan 1 1979

Fingerprint

Methysergide
Narcolepsy
Propranolol
Cataplexy
REM Sleep
Sleep
Serotonin Antagonists
Serotonin Receptors
Serotonin
Therapeutics
Central Nervous System

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Kales, A., Soldatos, C. R., Cadieux, R., Bixler, E. O., Tan, T. L., & Scharf, M. B. (1979). Propranolol in the treatment of narcolepsy. Annals of internal medicine, 91(5), 741-743. https://doi.org/10.7326/0003-4819-91-5-741
Kales, A. ; Soldatos, C. R. ; Cadieux, R. ; Bixler, E. O. ; Tan, T. L. ; Scharf, M. B. / Propranolol in the treatment of narcolepsy. In: Annals of internal medicine. 1979 ; Vol. 91, No. 5. pp. 741-743.
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Kales, A, Soldatos, CR, Cadieux, R, Bixler, EO, Tan, TL & Scharf, MB 1979, 'Propranolol in the treatment of narcolepsy', Annals of internal medicine, vol. 91, no. 5, pp. 741-743. https://doi.org/10.7326/0003-4819-91-5-741

Propranolol in the treatment of narcolepsy. / Kales, A.; Soldatos, C. R.; Cadieux, R.; Bixler, E. O.; Tan, T. L.; Scharf, M. B.

In: Annals of internal medicine, Vol. 91, No. 5, 01.01.1979, p. 741-743.

Research output: Contribution to journalArticle

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AU - Kales, A.

AU - Soldatos, C. R.

AU - Cadieux, R.

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AU - Scharf, M. B.

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AB - Serotoninergic systems are thought to be involved in production of slow-wave sleep and priming mechanisms that initiate REM sleep, whereas a dysfunction of both non-REM and REM sleep has been identified in narcolepsy with cataplexy. More recently, propranolol was shown to be an antagonist of serotonin's activity in the central nervous system, a property apparently related to a serotonin-receptor blocking effect similar in magnitude to that of methysergide. Our hypothesis that the effect of propranolol on narcolepsy is a function of its serotonin-blocking properties is supported by the reported effectiveness of methysergide in treating narcolepsy; methysergide clearly ameliorated sleep attacks, like propranolol in our study, whereas its effects on cataplexy varied.

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Kales A, Soldatos CR, Cadieux R, Bixler EO, Tan TL, Scharf MB. Propranolol in the treatment of narcolepsy. Annals of internal medicine. 1979 Jan 1;91(5):741-743. https://doi.org/10.7326/0003-4819-91-5-741