Prospecting for aptamers in the human genome

Philip C. Bevilacqua; Peter C. Breen; Pallavi Thaplyal

doi:10.1016/j.chembiol.2012.10.001

Prospecting for aptamers in the human genome

Philip C. Bevilacqua, Peter C. Breen, Pallavi Thaplyal

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Aptamers are RNA molecules that bind small molecules. They were originally isolated from random libraries and then found in bacteria. In this issue of Chemistry & Biology, Vu et al. demonstrate that a motif for an adenosine aptamer occurs in human and bacterial genomes and binds AMP and ATP in vitro.

Original language	English (US)
Pages (from-to)	1218-1220
Number of pages	3
Journal	Chemistry and Biology
Volume	19
Issue number	10
DOIs	https://doi.org/10.1016/j.chembiol.2012.10.001
State	Published - Oct 26 2012

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/j.chembiol.2012.10.001

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title = "Prospecting for aptamers in the human genome",

abstract = "Aptamers are RNA molecules that bind small molecules. They were originally isolated from random libraries and then found in bacteria. In this issue of Chemistry & Biology, Vu et al. demonstrate that a motif for an adenosine aptamer occurs in human and bacterial genomes and binds AMP and ATP in vitro.",

author = "Bevilacqua, {Philip C.} and Breen, {Peter C.} and Pallavi Thaplyal",

note = "Funding Information: The authors would like to thank NSF (Grant CHE-1213667) for its support.",

year = "2012",

month = oct,

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doi = "10.1016/j.chembiol.2012.10.001",

language = "English (US)",

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pages = "1218--1220",

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T1 - Prospecting for aptamers in the human genome

AU - Bevilacqua, Philip C.

AU - Breen, Peter C.

AU - Thaplyal, Pallavi

N1 - Funding Information: The authors would like to thank NSF (Grant CHE-1213667) for its support.

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Aptamers are RNA molecules that bind small molecules. They were originally isolated from random libraries and then found in bacteria. In this issue of Chemistry & Biology, Vu et al. demonstrate that a motif for an adenosine aptamer occurs in human and bacterial genomes and binds AMP and ATP in vitro.

AB - Aptamers are RNA molecules that bind small molecules. They were originally isolated from random libraries and then found in bacteria. In this issue of Chemistry & Biology, Vu et al. demonstrate that a motif for an adenosine aptamer occurs in human and bacterial genomes and binds AMP and ATP in vitro.

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DO - 10.1016/j.chembiol.2012.10.001

M3 - Short survey

C2 - 23102215

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SP - 1218

EP - 1220

JO - Cell Chemical Biology

JF - Cell Chemical Biology

IS - 10

ER -

Prospecting for aptamers in the human genome

Abstract

All Science Journal Classification (ASJC) codes

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