Prospective comparison of course of disability in antipsychotic-treated and untreated schizophrenia patients

J. Thirthalli, Venkatesh Basappa Krishnamurthy, K. V. Kishorekumar, U. Arunachala, G. Venkatasubramanian, D. K. Subbakrishna, B. N. Gangadhar

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Objective: To compare the course of disability in schizophrenia patients receiving antipsychotics and those remaining untreated in a rural community. Method: Of 215 schizophrenia patients identified in a rural south Indian community, 58% were not receiving antipsychotics. Trained raters assessed the disability in 190 of these at baseline and after 1 year. The course of disability in those who remained untreated was compared with that in those who received antipsychotics. Results: Mean disability scores remained virtually unchanged in those who remained untreated, but showed a significant decline (indicating decrement in disability) in those who continued to receive antipsychotics and in those in whom antipsychotic treatment was initiated (P < 0.001; group × occasion effect). The proportion of patients classified as 'disabled' declined significantly in the treated group (P < 0.01), but remained the same in the untreated group. Conclusion: Disability in untreated schizophrenia patients remains unchanged over time. Treatment with antipsychotics in the community results in a considerable reduction in disability.

Original languageEnglish (US)
Pages (from-to)209-217
Number of pages9
JournalActa Psychiatrica Scandinavica
Volume119
Issue number3
DOIs
StatePublished - Mar 1 2009

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Prospective comparison of course of disability in antipsychotic-treated and untreated schizophrenia patients'. Together they form a unique fingerprint.

  • Cite this

    Thirthalli, J., Basappa Krishnamurthy, V., Kishorekumar, K. V., Arunachala, U., Venkatasubramanian, G., Subbakrishna, D. K., & Gangadhar, B. N. (2009). Prospective comparison of course of disability in antipsychotic-treated and untreated schizophrenia patients. Acta Psychiatrica Scandinavica, 119(3), 209-217. https://doi.org/10.1111/j.1600-0447.2008.01299.x