Prospective comparison of course of disability in antipsychotic-treated and untreated schizophrenia patients

J. Thirthalli, Venkatesh Basappa Krishnamurthy, K. V. Kishorekumar, U. Arunachala, G. Venkatasubramanian, D. K. Subbakrishna, B. N. Gangadhar

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Objective: To compare the course of disability in schizophrenia patients receiving antipsychotics and those remaining untreated in a rural community. Method: Of 215 schizophrenia patients identified in a rural south Indian community, 58% were not receiving antipsychotics. Trained raters assessed the disability in 190 of these at baseline and after 1 year. The course of disability in those who remained untreated was compared with that in those who received antipsychotics. Results: Mean disability scores remained virtually unchanged in those who remained untreated, but showed a significant decline (indicating decrement in disability) in those who continued to receive antipsychotics and in those in whom antipsychotic treatment was initiated (P < 0.001; group × occasion effect). The proportion of patients classified as 'disabled' declined significantly in the treated group (P < 0.01), but remained the same in the untreated group. Conclusion: Disability in untreated schizophrenia patients remains unchanged over time. Treatment with antipsychotics in the community results in a considerable reduction in disability.

Original languageEnglish (US)
Pages (from-to)209-217
Number of pages9
JournalActa Psychiatrica Scandinavica
Volume119
Issue number3
DOIs
StatePublished - Mar 1 2009

Fingerprint

Antipsychotic Agents
Schizophrenia
Rural Population
Therapeutics

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

Thirthalli, J., Basappa Krishnamurthy, V., Kishorekumar, K. V., Arunachala, U., Venkatasubramanian, G., Subbakrishna, D. K., & Gangadhar, B. N. (2009). Prospective comparison of course of disability in antipsychotic-treated and untreated schizophrenia patients. Acta Psychiatrica Scandinavica, 119(3), 209-217. https://doi.org/10.1111/j.1600-0447.2008.01299.x
Thirthalli, J. ; Basappa Krishnamurthy, Venkatesh ; Kishorekumar, K. V. ; Arunachala, U. ; Venkatasubramanian, G. ; Subbakrishna, D. K. ; Gangadhar, B. N. / Prospective comparison of course of disability in antipsychotic-treated and untreated schizophrenia patients. In: Acta Psychiatrica Scandinavica. 2009 ; Vol. 119, No. 3. pp. 209-217.
@article{ae16ef6dad104f58b97037bcc7383a60,
title = "Prospective comparison of course of disability in antipsychotic-treated and untreated schizophrenia patients",
abstract = "Objective: To compare the course of disability in schizophrenia patients receiving antipsychotics and those remaining untreated in a rural community. Method: Of 215 schizophrenia patients identified in a rural south Indian community, 58{\%} were not receiving antipsychotics. Trained raters assessed the disability in 190 of these at baseline and after 1 year. The course of disability in those who remained untreated was compared with that in those who received antipsychotics. Results: Mean disability scores remained virtually unchanged in those who remained untreated, but showed a significant decline (indicating decrement in disability) in those who continued to receive antipsychotics and in those in whom antipsychotic treatment was initiated (P < 0.001; group × occasion effect). The proportion of patients classified as 'disabled' declined significantly in the treated group (P < 0.01), but remained the same in the untreated group. Conclusion: Disability in untreated schizophrenia patients remains unchanged over time. Treatment with antipsychotics in the community results in a considerable reduction in disability.",
author = "J. Thirthalli and {Basappa Krishnamurthy}, Venkatesh and Kishorekumar, {K. V.} and U. Arunachala and G. Venkatasubramanian and Subbakrishna, {D. K.} and Gangadhar, {B. N.}",
year = "2009",
month = "3",
day = "1",
doi = "10.1111/j.1600-0447.2008.01299.x",
language = "English (US)",
volume = "119",
pages = "209--217",
journal = "Acta Psychiatrica Scandinavica",
issn = "0001-690X",
publisher = "Wiley-Blackwell",
number = "3",

}

Thirthalli, J, Basappa Krishnamurthy, V, Kishorekumar, KV, Arunachala, U, Venkatasubramanian, G, Subbakrishna, DK & Gangadhar, BN 2009, 'Prospective comparison of course of disability in antipsychotic-treated and untreated schizophrenia patients', Acta Psychiatrica Scandinavica, vol. 119, no. 3, pp. 209-217. https://doi.org/10.1111/j.1600-0447.2008.01299.x

Prospective comparison of course of disability in antipsychotic-treated and untreated schizophrenia patients. / Thirthalli, J.; Basappa Krishnamurthy, Venkatesh; Kishorekumar, K. V.; Arunachala, U.; Venkatasubramanian, G.; Subbakrishna, D. K.; Gangadhar, B. N.

In: Acta Psychiatrica Scandinavica, Vol. 119, No. 3, 01.03.2009, p. 209-217.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prospective comparison of course of disability in antipsychotic-treated and untreated schizophrenia patients

AU - Thirthalli, J.

AU - Basappa Krishnamurthy, Venkatesh

AU - Kishorekumar, K. V.

AU - Arunachala, U.

AU - Venkatasubramanian, G.

AU - Subbakrishna, D. K.

AU - Gangadhar, B. N.

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Objective: To compare the course of disability in schizophrenia patients receiving antipsychotics and those remaining untreated in a rural community. Method: Of 215 schizophrenia patients identified in a rural south Indian community, 58% were not receiving antipsychotics. Trained raters assessed the disability in 190 of these at baseline and after 1 year. The course of disability in those who remained untreated was compared with that in those who received antipsychotics. Results: Mean disability scores remained virtually unchanged in those who remained untreated, but showed a significant decline (indicating decrement in disability) in those who continued to receive antipsychotics and in those in whom antipsychotic treatment was initiated (P < 0.001; group × occasion effect). The proportion of patients classified as 'disabled' declined significantly in the treated group (P < 0.01), but remained the same in the untreated group. Conclusion: Disability in untreated schizophrenia patients remains unchanged over time. Treatment with antipsychotics in the community results in a considerable reduction in disability.

AB - Objective: To compare the course of disability in schizophrenia patients receiving antipsychotics and those remaining untreated in a rural community. Method: Of 215 schizophrenia patients identified in a rural south Indian community, 58% were not receiving antipsychotics. Trained raters assessed the disability in 190 of these at baseline and after 1 year. The course of disability in those who remained untreated was compared with that in those who received antipsychotics. Results: Mean disability scores remained virtually unchanged in those who remained untreated, but showed a significant decline (indicating decrement in disability) in those who continued to receive antipsychotics and in those in whom antipsychotic treatment was initiated (P < 0.001; group × occasion effect). The proportion of patients classified as 'disabled' declined significantly in the treated group (P < 0.01), but remained the same in the untreated group. Conclusion: Disability in untreated schizophrenia patients remains unchanged over time. Treatment with antipsychotics in the community results in a considerable reduction in disability.

UR - http://www.scopus.com/inward/record.url?scp=58849106327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58849106327&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0447.2008.01299.x

DO - 10.1111/j.1600-0447.2008.01299.x

M3 - Article

VL - 119

SP - 209

EP - 217

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 3

ER -