Abstract
Objective: To prospectively examine whether use of statins is associated with altered risk of Parkinson disease (PD). Design, Setting, and Participants: A prospective study including 38 192 men and 90 874 women participating in 2 ongoing US cohorts, the Health Professional Follow-up Study and the Nurses' Health Study, was conducted. Information on regular cholesterol-lowering drug use (≥2 times/wk) was collected in 1994 in both cohorts via questionnaire. Relative risks (RRs) and 95% CIs were computed using Cox proportional hazards models adjusting for age, smoking, caffeine intake, duration of hypercholesterolemia, and other covariates. Main Outcome Measure: Incident PD. Results: During 12 years of follow-up (1994-2006), we documented 644 incident PD cases (338 women and 306 men). The risk of PD was lower among current statin users (adjusted pooled RR=0.74; 95% CI, 0.54-1.00; P=.049) relative to nonusers. A significant association was observed in participants younger than 60 years at baseline (adjusted pooled RR=0.31; 95% CI, 0.11-0.86; P=.02) but not among those who were older (adjusted pooled RR=0.83; 95% CI, 0.60-1.14; P=.25) (P for interaction=. 03). Conclusions: We found that regular use of statins was associated with a modest reduction in PD risk. The possibility that some statins may reduce PD risk deserves further consideration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 380-384 |
| Number of pages | 5 |
| Journal | Archives of Neurology |
| Volume | 69 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2012 |
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All Science Journal Classification (ASJC) codes
- Arts and Humanities (miscellaneous)
- Clinical Neurology
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Prospective study of statin use and risk of Parkinson disease. / Gao, Xiang; Simon, Kelly C.; Schwarzschild, Michael A.; Ascherio, Alberto.
In: Archives of Neurology, Vol. 69, No. 3, 01.03.2012, p. 380-384.Research output: Contribution to journal › Article
TY - JOUR
T1 - Prospective study of statin use and risk of Parkinson disease
AU - Gao, Xiang
AU - Simon, Kelly C.
AU - Schwarzschild, Michael A.
AU - Ascherio, Alberto
PY - 2012/3/1
Y1 - 2012/3/1
N2 - Objective: To prospectively examine whether use of statins is associated with altered risk of Parkinson disease (PD). Design, Setting, and Participants: A prospective study including 38 192 men and 90 874 women participating in 2 ongoing US cohorts, the Health Professional Follow-up Study and the Nurses' Health Study, was conducted. Information on regular cholesterol-lowering drug use (≥2 times/wk) was collected in 1994 in both cohorts via questionnaire. Relative risks (RRs) and 95% CIs were computed using Cox proportional hazards models adjusting for age, smoking, caffeine intake, duration of hypercholesterolemia, and other covariates. Main Outcome Measure: Incident PD. Results: During 12 years of follow-up (1994-2006), we documented 644 incident PD cases (338 women and 306 men). The risk of PD was lower among current statin users (adjusted pooled RR=0.74; 95% CI, 0.54-1.00; P=.049) relative to nonusers. A significant association was observed in participants younger than 60 years at baseline (adjusted pooled RR=0.31; 95% CI, 0.11-0.86; P=.02) but not among those who were older (adjusted pooled RR=0.83; 95% CI, 0.60-1.14; P=.25) (P for interaction=. 03). Conclusions: We found that regular use of statins was associated with a modest reduction in PD risk. The possibility that some statins may reduce PD risk deserves further consideration.
AB - Objective: To prospectively examine whether use of statins is associated with altered risk of Parkinson disease (PD). Design, Setting, and Participants: A prospective study including 38 192 men and 90 874 women participating in 2 ongoing US cohorts, the Health Professional Follow-up Study and the Nurses' Health Study, was conducted. Information on regular cholesterol-lowering drug use (≥2 times/wk) was collected in 1994 in both cohorts via questionnaire. Relative risks (RRs) and 95% CIs were computed using Cox proportional hazards models adjusting for age, smoking, caffeine intake, duration of hypercholesterolemia, and other covariates. Main Outcome Measure: Incident PD. Results: During 12 years of follow-up (1994-2006), we documented 644 incident PD cases (338 women and 306 men). The risk of PD was lower among current statin users (adjusted pooled RR=0.74; 95% CI, 0.54-1.00; P=.049) relative to nonusers. A significant association was observed in participants younger than 60 years at baseline (adjusted pooled RR=0.31; 95% CI, 0.11-0.86; P=.02) but not among those who were older (adjusted pooled RR=0.83; 95% CI, 0.60-1.14; P=.25) (P for interaction=. 03). Conclusions: We found that regular use of statins was associated with a modest reduction in PD risk. The possibility that some statins may reduce PD risk deserves further consideration.
UR - http://www.scopus.com/inward/record.url?scp=84858611748&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858611748&partnerID=8YFLogxK
U2 - 10.1001/archneurol.2011.1060
DO - 10.1001/archneurol.2011.1060
M3 - Article
C2 - 22410446
AN - SCOPUS:84858611748
VL - 69
SP - 380
EP - 384
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 3
ER -