Prospective study of statin use and risk of Parkinson disease

Xiang Gao, Kelly C. Simon, Michael A. Schwarzschild, Alberto Ascherio

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Objective: To prospectively examine whether use of statins is associated with altered risk of Parkinson disease (PD). Design, Setting, and Participants: A prospective study including 38 192 men and 90 874 women participating in 2 ongoing US cohorts, the Health Professional Follow-up Study and the Nurses' Health Study, was conducted. Information on regular cholesterol-lowering drug use (≥2 times/wk) was collected in 1994 in both cohorts via questionnaire. Relative risks (RRs) and 95% CIs were computed using Cox proportional hazards models adjusting for age, smoking, caffeine intake, duration of hypercholesterolemia, and other covariates. Main Outcome Measure: Incident PD. Results: During 12 years of follow-up (1994-2006), we documented 644 incident PD cases (338 women and 306 men). The risk of PD was lower among current statin users (adjusted pooled RR=0.74; 95% CI, 0.54-1.00; P=.049) relative to nonusers. A significant association was observed in participants younger than 60 years at baseline (adjusted pooled RR=0.31; 95% CI, 0.11-0.86; P=.02) but not among those who were older (adjusted pooled RR=0.83; 95% CI, 0.60-1.14; P=.25) (P for interaction=. 03). Conclusions: We found that regular use of statins was associated with a modest reduction in PD risk. The possibility that some statins may reduce PD risk deserves further consideration.

Original languageEnglish (US)
Pages (from-to)380-384
Number of pages5
JournalArchives of Neurology
Volume69
Issue number3
DOIs
StatePublished - Mar 1 2012

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Parkinson Disease
Prospective Studies
Parkinson's Disease
Health
Hypercholesterolemia
Caffeine
Proportional Hazards Models
Smoking
Nurses
Cholesterol
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Gao, Xiang ; Simon, Kelly C. ; Schwarzschild, Michael A. ; Ascherio, Alberto. / Prospective study of statin use and risk of Parkinson disease. In: Archives of Neurology. 2012 ; Vol. 69, No. 3. pp. 380-384.
@article{0642e38ea516437b85497e10ea2f7a88,
title = "Prospective study of statin use and risk of Parkinson disease",
abstract = "Objective: To prospectively examine whether use of statins is associated with altered risk of Parkinson disease (PD). Design, Setting, and Participants: A prospective study including 38 192 men and 90 874 women participating in 2 ongoing US cohorts, the Health Professional Follow-up Study and the Nurses' Health Study, was conducted. Information on regular cholesterol-lowering drug use (≥2 times/wk) was collected in 1994 in both cohorts via questionnaire. Relative risks (RRs) and 95{\%} CIs were computed using Cox proportional hazards models adjusting for age, smoking, caffeine intake, duration of hypercholesterolemia, and other covariates. Main Outcome Measure: Incident PD. Results: During 12 years of follow-up (1994-2006), we documented 644 incident PD cases (338 women and 306 men). The risk of PD was lower among current statin users (adjusted pooled RR=0.74; 95{\%} CI, 0.54-1.00; P=.049) relative to nonusers. A significant association was observed in participants younger than 60 years at baseline (adjusted pooled RR=0.31; 95{\%} CI, 0.11-0.86; P=.02) but not among those who were older (adjusted pooled RR=0.83; 95{\%} CI, 0.60-1.14; P=.25) (P for interaction=. 03). Conclusions: We found that regular use of statins was associated with a modest reduction in PD risk. The possibility that some statins may reduce PD risk deserves further consideration.",
author = "Xiang Gao and Simon, {Kelly C.} and Schwarzschild, {Michael A.} and Alberto Ascherio",
year = "2012",
month = "3",
day = "1",
doi = "10.1001/archneurol.2011.1060",
language = "English (US)",
volume = "69",
pages = "380--384",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "3",

}

Prospective study of statin use and risk of Parkinson disease. / Gao, Xiang; Simon, Kelly C.; Schwarzschild, Michael A.; Ascherio, Alberto.

In: Archives of Neurology, Vol. 69, No. 3, 01.03.2012, p. 380-384.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prospective study of statin use and risk of Parkinson disease

AU - Gao, Xiang

AU - Simon, Kelly C.

AU - Schwarzschild, Michael A.

AU - Ascherio, Alberto

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Objective: To prospectively examine whether use of statins is associated with altered risk of Parkinson disease (PD). Design, Setting, and Participants: A prospective study including 38 192 men and 90 874 women participating in 2 ongoing US cohorts, the Health Professional Follow-up Study and the Nurses' Health Study, was conducted. Information on regular cholesterol-lowering drug use (≥2 times/wk) was collected in 1994 in both cohorts via questionnaire. Relative risks (RRs) and 95% CIs were computed using Cox proportional hazards models adjusting for age, smoking, caffeine intake, duration of hypercholesterolemia, and other covariates. Main Outcome Measure: Incident PD. Results: During 12 years of follow-up (1994-2006), we documented 644 incident PD cases (338 women and 306 men). The risk of PD was lower among current statin users (adjusted pooled RR=0.74; 95% CI, 0.54-1.00; P=.049) relative to nonusers. A significant association was observed in participants younger than 60 years at baseline (adjusted pooled RR=0.31; 95% CI, 0.11-0.86; P=.02) but not among those who were older (adjusted pooled RR=0.83; 95% CI, 0.60-1.14; P=.25) (P for interaction=. 03). Conclusions: We found that regular use of statins was associated with a modest reduction in PD risk. The possibility that some statins may reduce PD risk deserves further consideration.

AB - Objective: To prospectively examine whether use of statins is associated with altered risk of Parkinson disease (PD). Design, Setting, and Participants: A prospective study including 38 192 men and 90 874 women participating in 2 ongoing US cohorts, the Health Professional Follow-up Study and the Nurses' Health Study, was conducted. Information on regular cholesterol-lowering drug use (≥2 times/wk) was collected in 1994 in both cohorts via questionnaire. Relative risks (RRs) and 95% CIs were computed using Cox proportional hazards models adjusting for age, smoking, caffeine intake, duration of hypercholesterolemia, and other covariates. Main Outcome Measure: Incident PD. Results: During 12 years of follow-up (1994-2006), we documented 644 incident PD cases (338 women and 306 men). The risk of PD was lower among current statin users (adjusted pooled RR=0.74; 95% CI, 0.54-1.00; P=.049) relative to nonusers. A significant association was observed in participants younger than 60 years at baseline (adjusted pooled RR=0.31; 95% CI, 0.11-0.86; P=.02) but not among those who were older (adjusted pooled RR=0.83; 95% CI, 0.60-1.14; P=.25) (P for interaction=. 03). Conclusions: We found that regular use of statins was associated with a modest reduction in PD risk. The possibility that some statins may reduce PD risk deserves further consideration.

UR - http://www.scopus.com/inward/record.url?scp=84858611748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858611748&partnerID=8YFLogxK

U2 - 10.1001/archneurol.2011.1060

DO - 10.1001/archneurol.2011.1060

M3 - Article

C2 - 22410446

AN - SCOPUS:84858611748

VL - 69

SP - 380

EP - 384

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 3

ER -