Prostaglandin F in monkey uterine fluid during the menstrual cycle and following steroid treatment

Laurence M. Demers, Koji Yoshinaga, Roy O. Greep

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Prostaglandin F levels were determined in monkey uterine fluid collected daily from a silicone tubing collection system surgically installed in adult female rhesus monkeys. Sampling was obtained from intact and ovariectomized - hormone treated monkeys. During the primate menstrual cycle, uterine fluid prostaglandin F levels showed a cyclic pattern in concentration with highest values recorded during the 18-20th day of the cycle. Estrogen treatment to the ovariectomized female elicited a striking and marked increase in uterine fluid prostaglandin F levels while progesterone treatment had little effect. These results suggest that the presence of uterine fluid prostaglandin F is estrogen dependent and may be causely related to the control of menstrual cyclicity.

Original languageEnglish (US)
Pages (from-to)513-519
Number of pages7
JournalProstaglandins
Volume5
Issue number6
DOIs
StatePublished - Mar 25 1974

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology

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