Prostaglandin levels in endometrial jet wash specimens in patients with dysmenorrhea before and after indomethacin therapy

David R. Halbert, Laurence M. Demers, John Fontana, D. E.Darnell Jones

Research output: Contribution to journalArticle

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A patient with functional primary dysmenorrhea of over two years duration was subjected to the endometrial jet wash technique during the period of active menstrual flow. Prostaglandin F analysis of the jet washings revealed significantly elevated levels during menstruation over normal control levels. Following indomethacin therapy, jet wash prostaglandin F levels were dramatically reduced and the patient became asymptomatic. A cause and effect relationship between prostaglandin F and dysmenorrhea is suggested by these studies.

Original languageEnglish (US)
Pages (from-to)1047-1056
Number of pages10
Issue number6
StatePublished - 1975


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology

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