Prostaglandin production in chronic progressive multiple sclerosis

Judith A. Aberg, Laurence M. Demers, Paula J. Romano, Richard B. Tenser

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Peripheral blood monocytes have been implicated in the immune reactions that accompany demyelination in patients with multiple sclerosis (MS). We measured prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) release from peripheral monocytes exposed in vitro to complement. Our studies suggest that there is a significantly higher production of PGE2 in monocytes from patients with chronic progressive MS than in those with exacerbation or remitting MS and healthy controls. No significant differences in TxB2release were noted between the three groups.

Original languageEnglish (US)
Pages (from-to)246-250
Number of pages5
JournalJournal of Clinical Laboratory Analysis
Volume4
Issue number4
DOIs
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Clinical Biochemistry
  • Medical Laboratory Technology
  • Biochemistry, medical
  • Microbiology (medical)

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