Prostaglandins in menstrual fluid in menorrhagia and dysmenorrhoea

MARGARET C.P. REES, ANNE B.M. ANDERSON, LAURENCE M. DEMERS, A. C. TURNBULL

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Menstrual fluid was collected in vaginal cups inserted for 2 h during the first 2 days of menstruation and menstrual serum concentrations of prostaglandins PGF and PGE2 were measured by radio‐immunoassay. In 16 women from whom menstrual fluid was collected on both days, PGF and PGE2 concentrations were significantly higher on day 1 than on day 2. The highest concentrations of PGF 2α and PGE2 were found in dysmenorrhoeic women on day 1. In non‐dysmenorrhoeic women, the amount of PGF and PGE2 collected in 2 h correlated directly with total menstrual blood loss. There was no statistically significant difference in the amount of prostaglandins collected in 2 h in pain‐free menorrhagic women and dysmenorrhoeic women with normal loss. There was also no significant 9‐ketoreductase or 9‐hydroxydehydro‐genase activity present in menstrual fluid which could suggest PGE2 to PGF interconversion.

Original languageEnglish (US)
Pages (from-to)673-680
Number of pages8
JournalBJOG: An International Journal of Obstetrics & Gynaecology
Volume91
Issue number7
DOIs
StatePublished - Jul 1984

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

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