Prostate cancer topography and patterns of lymph node metastasis

Yuji Tokuda, Lauren J. Carlino, Anuradha Gopalan, Satish K. Tickoo, Matthew G. Kaag, Bertrand Guillonneau, James A. Eastham, Howard I. Scher, Peter T. Scardino, Victor E. Reuter, Samson W. Fine

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Abstract

Pelvic lymph node (LN) metastasis is a well-recognized route of prostate cancer spread. However, the relationship between topography and the pathologic features of primary prostatic cancers and patterns of pelvic LN metastasis has not been well studied. We reviewed original slides of radical prostatectomies and pelvic LN dissections from 125 patients with LN metastasis and recorded a total number of LN excised/laterality of positive LN, and localization, staging parameters, lymphovascular invasion, and volume of primary tumors. LN QUANTITY AND DISTRIBUTION: 14.6 (mean) and 13 (median) LNs were resected. Seventy-six (61%), 33 (26%), and 16 (13%) cases had 1, 2, and >2 positive LNs; whereas 58, 44, and 20 cases had LN metastasis on the right, left, and bilaterally. PATHOLOGIC FEATURES: Eighty-six percent (108 of 125) and 37% (46 of 125) of the cases showed extraprostatic extension and seminal vesicle invasion, whereas 64% cased showed lymphovascular invasion. Mean and median total tumor volumes were 6.39 and 3.92 cm, with 50% and 90% Gleason patterns 4/5 in 105 (84%) and 73 (58%) cases, respectively. Correlation with Dominant Tumor Location: Dominant lesions on radical prostatectomy were as follows: 50 right lobe, 44 left lobe, and 31 bilateral lobe tumors. Fifteen of 50 (30%) right lobe and 18 of 44 (41%) left lobe dominant tumors had LN metastasis on the contralateral side. Only 4% (5 of 125) of the cases were associated with anterior dominant tumors. CONCLUSION: Thirty percent to 40% of LN metastases occurred contralateral to the dominant tumor. LN metastasis is overwhelmingly associated with high-grade, high-stage, and large volume disease. LN positivity is rarely associated with anterior dominant tumors.

Original languageEnglish (US)
Pages (from-to)1862-1867
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume34
Issue number12
DOIs
StatePublished - Dec 1 2010

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Prostatic Neoplasms
Lymph Nodes
Neoplasm Metastasis
Neoplasms
Prostatectomy
Tumor Burden
Seminal Vesicles
Lymph Node Excision

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Tokuda, Y., Carlino, L. J., Gopalan, A., Tickoo, S. K., Kaag, M. G., Guillonneau, B., ... Fine, S. W. (2010). Prostate cancer topography and patterns of lymph node metastasis. American Journal of Surgical Pathology, 34(12), 1862-1867. https://doi.org/10.1097/PAS.0b013e3181fc679e
Tokuda, Yuji ; Carlino, Lauren J. ; Gopalan, Anuradha ; Tickoo, Satish K. ; Kaag, Matthew G. ; Guillonneau, Bertrand ; Eastham, James A. ; Scher, Howard I. ; Scardino, Peter T. ; Reuter, Victor E. ; Fine, Samson W. / Prostate cancer topography and patterns of lymph node metastasis. In: American Journal of Surgical Pathology. 2010 ; Vol. 34, No. 12. pp. 1862-1867.
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title = "Prostate cancer topography and patterns of lymph node metastasis",
abstract = "Pelvic lymph node (LN) metastasis is a well-recognized route of prostate cancer spread. However, the relationship between topography and the pathologic features of primary prostatic cancers and patterns of pelvic LN metastasis has not been well studied. We reviewed original slides of radical prostatectomies and pelvic LN dissections from 125 patients with LN metastasis and recorded a total number of LN excised/laterality of positive LN, and localization, staging parameters, lymphovascular invasion, and volume of primary tumors. LN QUANTITY AND DISTRIBUTION: 14.6 (mean) and 13 (median) LNs were resected. Seventy-six (61{\%}), 33 (26{\%}), and 16 (13{\%}) cases had 1, 2, and >2 positive LNs; whereas 58, 44, and 20 cases had LN metastasis on the right, left, and bilaterally. PATHOLOGIC FEATURES: Eighty-six percent (108 of 125) and 37{\%} (46 of 125) of the cases showed extraprostatic extension and seminal vesicle invasion, whereas 64{\%} cased showed lymphovascular invasion. Mean and median total tumor volumes were 6.39 and 3.92 cm, with 50{\%} and 90{\%} Gleason patterns 4/5 in 105 (84{\%}) and 73 (58{\%}) cases, respectively. Correlation with Dominant Tumor Location: Dominant lesions on radical prostatectomy were as follows: 50 right lobe, 44 left lobe, and 31 bilateral lobe tumors. Fifteen of 50 (30{\%}) right lobe and 18 of 44 (41{\%}) left lobe dominant tumors had LN metastasis on the contralateral side. Only 4{\%} (5 of 125) of the cases were associated with anterior dominant tumors. CONCLUSION: Thirty percent to 40{\%} of LN metastases occurred contralateral to the dominant tumor. LN metastasis is overwhelmingly associated with high-grade, high-stage, and large volume disease. LN positivity is rarely associated with anterior dominant tumors.",
author = "Yuji Tokuda and Carlino, {Lauren J.} and Anuradha Gopalan and Tickoo, {Satish K.} and Kaag, {Matthew G.} and Bertrand Guillonneau and Eastham, {James A.} and Scher, {Howard I.} and Scardino, {Peter T.} and Reuter, {Victor E.} and Fine, {Samson W.}",
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Tokuda, Y, Carlino, LJ, Gopalan, A, Tickoo, SK, Kaag, MG, Guillonneau, B, Eastham, JA, Scher, HI, Scardino, PT, Reuter, VE & Fine, SW 2010, 'Prostate cancer topography and patterns of lymph node metastasis', American Journal of Surgical Pathology, vol. 34, no. 12, pp. 1862-1867. https://doi.org/10.1097/PAS.0b013e3181fc679e

Prostate cancer topography and patterns of lymph node metastasis. / Tokuda, Yuji; Carlino, Lauren J.; Gopalan, Anuradha; Tickoo, Satish K.; Kaag, Matthew G.; Guillonneau, Bertrand; Eastham, James A.; Scher, Howard I.; Scardino, Peter T.; Reuter, Victor E.; Fine, Samson W.

In: American Journal of Surgical Pathology, Vol. 34, No. 12, 01.12.2010, p. 1862-1867.

Research output: Contribution to journalArticle

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T1 - Prostate cancer topography and patterns of lymph node metastasis

AU - Tokuda, Yuji

AU - Carlino, Lauren J.

AU - Gopalan, Anuradha

AU - Tickoo, Satish K.

AU - Kaag, Matthew G.

AU - Guillonneau, Bertrand

AU - Eastham, James A.

AU - Scher, Howard I.

AU - Scardino, Peter T.

AU - Reuter, Victor E.

AU - Fine, Samson W.

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Pelvic lymph node (LN) metastasis is a well-recognized route of prostate cancer spread. However, the relationship between topography and the pathologic features of primary prostatic cancers and patterns of pelvic LN metastasis has not been well studied. We reviewed original slides of radical prostatectomies and pelvic LN dissections from 125 patients with LN metastasis and recorded a total number of LN excised/laterality of positive LN, and localization, staging parameters, lymphovascular invasion, and volume of primary tumors. LN QUANTITY AND DISTRIBUTION: 14.6 (mean) and 13 (median) LNs were resected. Seventy-six (61%), 33 (26%), and 16 (13%) cases had 1, 2, and >2 positive LNs; whereas 58, 44, and 20 cases had LN metastasis on the right, left, and bilaterally. PATHOLOGIC FEATURES: Eighty-six percent (108 of 125) and 37% (46 of 125) of the cases showed extraprostatic extension and seminal vesicle invasion, whereas 64% cased showed lymphovascular invasion. Mean and median total tumor volumes were 6.39 and 3.92 cm, with 50% and 90% Gleason patterns 4/5 in 105 (84%) and 73 (58%) cases, respectively. Correlation with Dominant Tumor Location: Dominant lesions on radical prostatectomy were as follows: 50 right lobe, 44 left lobe, and 31 bilateral lobe tumors. Fifteen of 50 (30%) right lobe and 18 of 44 (41%) left lobe dominant tumors had LN metastasis on the contralateral side. Only 4% (5 of 125) of the cases were associated with anterior dominant tumors. CONCLUSION: Thirty percent to 40% of LN metastases occurred contralateral to the dominant tumor. LN metastasis is overwhelmingly associated with high-grade, high-stage, and large volume disease. LN positivity is rarely associated with anterior dominant tumors.

AB - Pelvic lymph node (LN) metastasis is a well-recognized route of prostate cancer spread. However, the relationship between topography and the pathologic features of primary prostatic cancers and patterns of pelvic LN metastasis has not been well studied. We reviewed original slides of radical prostatectomies and pelvic LN dissections from 125 patients with LN metastasis and recorded a total number of LN excised/laterality of positive LN, and localization, staging parameters, lymphovascular invasion, and volume of primary tumors. LN QUANTITY AND DISTRIBUTION: 14.6 (mean) and 13 (median) LNs were resected. Seventy-six (61%), 33 (26%), and 16 (13%) cases had 1, 2, and >2 positive LNs; whereas 58, 44, and 20 cases had LN metastasis on the right, left, and bilaterally. PATHOLOGIC FEATURES: Eighty-six percent (108 of 125) and 37% (46 of 125) of the cases showed extraprostatic extension and seminal vesicle invasion, whereas 64% cased showed lymphovascular invasion. Mean and median total tumor volumes were 6.39 and 3.92 cm, with 50% and 90% Gleason patterns 4/5 in 105 (84%) and 73 (58%) cases, respectively. Correlation with Dominant Tumor Location: Dominant lesions on radical prostatectomy were as follows: 50 right lobe, 44 left lobe, and 31 bilateral lobe tumors. Fifteen of 50 (30%) right lobe and 18 of 44 (41%) left lobe dominant tumors had LN metastasis on the contralateral side. Only 4% (5 of 125) of the cases were associated with anterior dominant tumors. CONCLUSION: Thirty percent to 40% of LN metastases occurred contralateral to the dominant tumor. LN metastasis is overwhelmingly associated with high-grade, high-stage, and large volume disease. LN positivity is rarely associated with anterior dominant tumors.

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