Protecting your tail: Regulation of cadherin degradation by p120-catenin

Andrew P. Kowalczyk, Albert B. Reynolds

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations

Abstract

Work in various model systems has yielded conflicting views of how p120-catenin participates in adherens junction assembly and regulation. A series of recent studies indicate that a core function of p120-catenin in mammalian cells is to regulate cadherin turnover by modulating the entry of cadherins into degradative endocytic pathways. By this mechanism, cellular levels of p120-catenin perform a 'rheostat' or 'set point' function that controls steady-state cadherin levels. These studies parallel a growing interest in the regulation of cadherin levels at the cell surface by membrane trafficking pathways. Collectively, the findings suggest exciting new roles for p120-catenin at the interface between cadherins and membrane trafficking machinery, and imply novel mechanisms by which p120-catenin may regulate cell adhesion and migration in the context of development and cancer.

Original languageEnglish (US)
Pages (from-to)522-527
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume16
Issue number5
DOIs
StatePublished - Oct 2004

All Science Journal Classification (ASJC) codes

  • Cell Biology

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