Protective effect of steroids in electrolyte-induced demyelination

A. M. Rojiani, J. W. Prineas, E. S. Cho

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Electrolyte-induced demyelination (EID), an experimental model for cen-tral pontine myelinolysis was produced in rats by inducing hyponatremia followed by hypernatremia. There was a marked reduction in the number and size of lesions developing in animals that were bled repeatedly by tail transection during induction of the disease. Subsequently a similar protective effect was produced in animals by injecting a single dose of dexamethasone, one hour before the induction of hyper-natremia. These findings suggest that steroids may be useful in preventing central pontine myelinolysis from developing in high risk patients requiring urgent correction of hyponatremia.

Original languageEnglish (US)
Pages (from-to)495-504
Number of pages10
JournalJournal of neuropathology and experimental neurology
Volume46
Issue number4
DOIs
StatePublished - Jul 1987

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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