Protective effect of total arasolides of aralia elata (Miq) seem on cardiomyopathy in rats with early stage diabetes and its mechanism

Shu Gang Xi, Xuexin Zhang, Wen Jie Zhang, Zheng Ren Wei, Chun Yan Zhao

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To discuss the effect of total arasolides of aralia elata (Miq) seem (TASAES) on cardiac function and protective effect on mgocardial structure in rats with early stage diabetes. Methods: The models of diabetic rats were made by an intra-abdominal injection of streptozotocin (STZ). Rats were divided into control group (C group), model group (M group) and TASAES 4.9, 9.8, 19.6 mg · kg -1 groups (T 1 , T 2 , T 3 groups). At the time of 8 weeks, the hemodynamic parameters were detected in various groups; ultrastructure of cardiomyocytes was observed under electron microscope; the expression of connective tissue growth factor (CTGF) was detected by RT-PCR technique at the molecular level. Results: Compared with model group, TASAES increased the absolute value of left ventricular systolic pressure (LVSP) and ±dp/dt max in diabetic rats, especially in high and middle dosage groups (P<0.05, P<0.01), it improved the ultrastructure of cardiomyocytes and reduced the expression of CTGF in high and middle dosage groups (P<0.01). Conclusion: TASAES can improve the cardiac function of diabetic rats in a dose dependent manner, and its protective effect may be related to the reduction of CTGF and enhancement of cardiac contractility.

Original languageEnglish (US)
Pages (from-to)209-213
Number of pages5
JournalJournal of Jilin University Medicine Edition
Volume34
Issue number2
StatePublished - Mar 28 2008

All Science Journal Classification (ASJC) codes

  • Pharmacology

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