Protein folding: Then and now

Yiwen Chen, Feng Ding, Huifen Nie, Adrian W. Serohijos, Shantanu Sharma, Kyle C. Wilcox, Shuangye Yin, Nikolay V. Dokholyan

Research output: Contribution to journalReview article

67 Scopus citations

Abstract

Over the past three decades the protein folding field has undergone monumental changes. Originally a purely academic question, how a protein folds has now become vital in understanding diseases and our abilities to rationally manipulate cellular life by engineering protein folding pathways. We review and contrast past and recent developments in the protein folding field. Specifically, we discuss the progress in our understanding of protein folding thermodynamics and kinetics, the properties of evasive intermediates, and unfolded states. We also discuss how some abnormalities in protein folding lead to protein aggregation and human diseases.

Original languageEnglish (US)
Pages (from-to)4-19
Number of pages16
JournalArchives of Biochemistry and Biophysics
Volume469
Issue number1
DOIs
StatePublished - Jan 1 2008

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology

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    Chen, Y., Ding, F., Nie, H., Serohijos, A. W., Sharma, S., Wilcox, K. C., Yin, S., & Dokholyan, N. V. (2008). Protein folding: Then and now. Archives of Biochemistry and Biophysics, 469(1), 4-19. https://doi.org/10.1016/j.abb.2007.05.014