Protein interactions and fluctuations in a proteomic network using an elastic network model

Melik C. Demirel, Ozlem Keskin

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A set of protein conformations are analyzed by normal mode analysis. An elastic network model is used to obtain fluctuation and cooperativity of residues with low amplitude fluctuations across different species. Slow modes that are associated with the function of proteins have common features among different protein structures. We show that the degree of flexibility of the protein is important for proteins to interact with other proteins and as the species gets more complex its proteins become more flexible. In the complex organism, higher cooperativity arises due to protein structure and connectivity.

Original languageEnglish (US)
Pages (from-to)381-386
Number of pages6
JournalJournal of Biomolecular Structure and Dynamics
Volume22
Issue number4
DOIs
StatePublished - Feb 2005

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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