Protein Kinase Mzeta Maintains Fear Memory in the Amygdala but Not in the Hippocampus

Janine L. Kwapis, Timothy J. Jarome, Mary E. Lonergan, Fred J. Helmstetter

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Recent work on the long-term stability of memory and synaptic plasticity has identified a potentially critical role for protein kinase Mzeta (PKMζ). PKMζ is a constitutively active, atypical isoform of protein kinase C that is believed to maintain long term potentiation at hippocampal synapses in vitro. In behaving animals, local inhibition of PKMζ disrupts spatial memory in the hippocampus and conditioned taste aversion memory in the insular cortex. The role of PKMζ in context fear memory is less clear. This study examined the role of PKMζ in amygdala and hippocampal neurons following a standard fear conditioning protocol. The results indicate that PKMζ inhibition in the amygdala, but not in the hippocampus, can disrupt fear memory. This suggests that PKMζ may only maintain select forms of memory in specific brain structures and does not participate in a universal memory storage mechanism.

Original languageEnglish (US)
Pages (from-to)844-850
Number of pages7
JournalBehavioral Neuroscience
Volume123
Issue number4
DOIs
StatePublished - Aug 1 2009

Fingerprint

Amygdala
Protein Kinases
Fear
Hippocampus
Neuronal Plasticity
Long-Term Memory
Long-Term Potentiation
Cerebral Cortex
Synapses
Protein Isoforms
Neurons
Brain

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Kwapis, Janine L. ; Jarome, Timothy J. ; Lonergan, Mary E. ; Helmstetter, Fred J. / Protein Kinase Mzeta Maintains Fear Memory in the Amygdala but Not in the Hippocampus. In: Behavioral Neuroscience. 2009 ; Vol. 123, No. 4. pp. 844-850.
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Protein Kinase Mzeta Maintains Fear Memory in the Amygdala but Not in the Hippocampus. / Kwapis, Janine L.; Jarome, Timothy J.; Lonergan, Mary E.; Helmstetter, Fred J.

In: Behavioral Neuroscience, Vol. 123, No. 4, 01.08.2009, p. 844-850.

Research output: Contribution to journalArticle

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