TY - JOUR
T1 - Proteins, platelets, and blood coagulation at biomaterial interfaces
AU - Xu, Li Chong
AU - Bauer, James W.
AU - Siedlecki, Christopher A.
N1 - Funding Information:
These studies were supported in part by NIH RO1 HL69965 , and the National Science Foundation ( DMR-0804873 ). The authors would like to thank Dr. Keith Milner, Dr. Erwin Vogler and Dr. Avantika Golas for numerous discussions and technical assistance.
Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Blood coagulation and platelet adhesion remain major impediments to the use of biomaterials in implantable medical devices. There is still significant controversy and question in the field regarding the role that surfaces play in this process. This manuscript addresses this topic area and reports on state of the art in the field. Particular emphasis is placed on the subject of surface engineering and surface measurements that allow for control and observation of surface-mediated biological responses in blood and test solutions. Appropriate use of surface texturing and chemical patterning methodologies allow for reduction of both blood coagulation and platelet adhesion, and new methods of surface interrogation at high resolution allow for measurement of the relevant biological factors.
AB - Blood coagulation and platelet adhesion remain major impediments to the use of biomaterials in implantable medical devices. There is still significant controversy and question in the field regarding the role that surfaces play in this process. This manuscript addresses this topic area and reports on state of the art in the field. Particular emphasis is placed on the subject of surface engineering and surface measurements that allow for control and observation of surface-mediated biological responses in blood and test solutions. Appropriate use of surface texturing and chemical patterning methodologies allow for reduction of both blood coagulation and platelet adhesion, and new methods of surface interrogation at high resolution allow for measurement of the relevant biological factors.
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U2 - 10.1016/j.colsurfb.2014.09.040
DO - 10.1016/j.colsurfb.2014.09.040
M3 - Article
C2 - 25448722
AN - SCOPUS:84910016348
SN - 0927-7765
VL - 124
SP - 49
EP - 68
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
ER -