Proteoglycomics: Recent progress and future challenges

Mellisa Ly, Tatiana N. Laremore, Robert J. Linhardt

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Proteoglycomics is a systematic study of structure, expression, and function of proteoglycans, a posttranslationally modified subset of a proteome. Although relying on the established technologies of proteomics and glycomics, proteoglycomics research requires unique approaches for elucidating structure-function relationships of both proteoglycan components, glycosaminoglycan chain, and core protein. This review discusses our current understanding of structure and function of proteoglycans, major players in the development, normal physiology, and disease. A brief outline of the proteoglycomic sample preparation and analysis is provided along with examples of several recent proteoglycomic studies. Unique challenges in the characterization of glycosaminoglycan component of proteoglycans are discussed, with emphasis on the many analytical tools used and the types of information they provide.

Original languageEnglish (US)
Pages (from-to)389-399
Number of pages11
JournalOMICS A Journal of Integrative Biology
Volume14
Issue number4
DOIs
StatePublished - Aug 1 2010

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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