Proteomic investigation of epigenetics in neuropychiatric disorders

A missing link between genetics and behavior?

Mariana D. Plazas-Mayorca, Kent Vrana

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Neuropsychiatric disorders affect a large segment of the human population and result in large costs to society. The majority of such disorders have unknown underlying causes. Recent evidence suggests an important role for epigenetic regulation in the emergence of neuropsychiatric disease. Epigenetics may provide a link between genetic and environmental factors and behavior. Epigenetic signaling involves changes on the structure of chromatin; such changes are often triggered and maintained by the post-translational modification of chromatin proteins and/or DNA. Recent proteomic technologies have enabled the study of epigenetic mechanisms in a high-throughput manner. This review will provide an overview of the major epigenetic pathways and modern techniques for their study, before focusing on experimental evidence supporting a strong role for epigenetics in selected psychiatric disorders such as depression, schizophrenia, and drug addiction. These results highlight a great need for the inclusion of the proteomic characterization of epigenetic mechanisms in the study of gene/disease associations in psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)58-65
Number of pages8
JournalJournal of Proteome Research
Volume10
Issue number1
DOIs
StatePublished - Jan 7 2011

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Epigenomics
Proteomics
Chromatin
Genes
Throughput
DNA
Psychiatry
Pharmaceutical Preparations
Costs
Proteins
Post Translational Protein Processing
Genetics
Substance-Related Disorders
Schizophrenia
Depression
Technology
Costs and Cost Analysis
Population

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Chemistry(all)

Cite this

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abstract = "Neuropsychiatric disorders affect a large segment of the human population and result in large costs to society. The majority of such disorders have unknown underlying causes. Recent evidence suggests an important role for epigenetic regulation in the emergence of neuropsychiatric disease. Epigenetics may provide a link between genetic and environmental factors and behavior. Epigenetic signaling involves changes on the structure of chromatin; such changes are often triggered and maintained by the post-translational modification of chromatin proteins and/or DNA. Recent proteomic technologies have enabled the study of epigenetic mechanisms in a high-throughput manner. This review will provide an overview of the major epigenetic pathways and modern techniques for their study, before focusing on experimental evidence supporting a strong role for epigenetics in selected psychiatric disorders such as depression, schizophrenia, and drug addiction. These results highlight a great need for the inclusion of the proteomic characterization of epigenetic mechanisms in the study of gene/disease associations in psychiatric disorders.",
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Proteomic investigation of epigenetics in neuropychiatric disorders : A missing link between genetics and behavior? / Plazas-Mayorca, Mariana D.; Vrana, Kent.

In: Journal of Proteome Research, Vol. 10, No. 1, 07.01.2011, p. 58-65.

Research output: Contribution to journalReview article

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