Proteostasis in the Hedgehog signaling pathway

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Abstract

The Hedgehog (Hh) signaling pathway is crucial for the development of vertebrate and invertebrate animals alike. Hh ligand binds its receptor Patched (Ptc), allowing the activation of the obligate signal transducer Smoothened (Smo). The levels and localizations of both Ptc and Smo are regulated by ubiquitination, and Smo is under additional regulation by phosphorylation and SUMOylation. Downstream of Smo, the Ci/Gli family of transcription factors regulates the transcriptional responses to Hh. Phosphorylation, ubiquitination and SUMOylation are important for the stability and localization of Ci/Gli proteins and Hh signaling output. Finally, Suppressor of Fused directly regulates Ci/Gli proteins and itself is under proteolytic regulation that is critical for normal Hh signaling.

Original languageEnglish (US)
Pages (from-to)153-163
Number of pages11
JournalSeminars in Cell and Developmental Biology
Volume93
DOIs
StatePublished - Sep 2019

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All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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