Pseudomelanosis duodeni in a postrenal transplant patient

Theresa Schuerle, Elie Aoun, Kofi Clarke

Research output: Contribution to journalArticle

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Abstract

Pseudomelanosis duodeni is a rare entity characterised by dark pigmented intracellular granules seen within macrophages that lie within the lamina propria of the duodenal villi. There is no known treatment, and the clinical signi ficance and long-term sequelae of this entity are unclear. We present a case of pseudomelanosis duodeni in a 54-year-old woman who presented with a 1-month history of nausea, vomiting and non-bloody diarrhoea. The medical history was signi ficant for diabetes mellitus type 2, end-stage renal disease status postkidney transplant, hypertension, anaemia of chronic disease and hypothyroidism. A gastroduodenal endoscopy revealed pigmented dark lesions in the duodenal mucosa. Biopsies from the second part of the duodenum and duodenal bulb showed pigmented macrophages in the lamina propria. The findings were consistent with duodenal melanosis. In spite of renal transplant with normalisation of renal function, the duodenal melanosis persists, which raises questions on the role of renal impairment in this entity.

Original languageEnglish (US)
JournalBMJ case reports
DOIs
StatePublished - Dec 10 2013

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Melanosis
Mucous Membrane
Transplants
Kidney
Macrophages
Hypothyroidism
Duodenum
Type 2 Diabetes Mellitus
Nausea
Endoscopy
Chronic Kidney Failure
Vomiting
Anemia
Diarrhea
Chronic Disease
Hypertension
Biopsy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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Pseudomelanosis duodeni in a postrenal transplant patient. / Schuerle, Theresa; Aoun, Elie; Clarke, Kofi.

In: BMJ case reports, 10.12.2013.

Research output: Contribution to journalArticle

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AU - Aoun, Elie

AU - Clarke, Kofi

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AB - Pseudomelanosis duodeni is a rare entity characterised by dark pigmented intracellular granules seen within macrophages that lie within the lamina propria of the duodenal villi. There is no known treatment, and the clinical signi ficance and long-term sequelae of this entity are unclear. We present a case of pseudomelanosis duodeni in a 54-year-old woman who presented with a 1-month history of nausea, vomiting and non-bloody diarrhoea. The medical history was signi ficant for diabetes mellitus type 2, end-stage renal disease status postkidney transplant, hypertension, anaemia of chronic disease and hypothyroidism. A gastroduodenal endoscopy revealed pigmented dark lesions in the duodenal mucosa. Biopsies from the second part of the duodenum and duodenal bulb showed pigmented macrophages in the lamina propria. The findings were consistent with duodenal melanosis. In spite of renal transplant with normalisation of renal function, the duodenal melanosis persists, which raises questions on the role of renal impairment in this entity.

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