Psychobiologische aspekte der posttraumatischen belastungsstorung

Translated title of the contribution: Psychobiological aspects of posttraumatic stress disorder

Ulrike Ehlert, D. Wagner, M. Heinrichs, Christine Marcelle Heim

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

The exposure to a traumatic event may result in posttraumatic stress disorder (PTSD), which is characterized by a complex symptomatology, clustered into three groups of symptoms, i.e. intrusive memories, avoidance behavior, and hyperarousal. Since PTSD is a stress reaction, alterations of stress-responses of neurobiological systems have been examined in patients suffering from PTSD. The investigation of biological parameters refers to the hypothalamic-pituitary-adrenal axis (HPA), studies of the noradrenergic and the endogenous opiate system as well as psychophysiological and neuroimaging studies. Besides others, the observed biological dysregulations refer to hypocortisolism with an enhanced negative feedback of the HPA axis, enhanced noradrenergic activity, and neuroanatomical changes. To elucidate the specifity of this findings for PTSD, the dysregulations will be discussed with reference to findings in major depression and somatoform disorders.

Translated title of the contributionPsychobiological aspects of posttraumatic stress disorder
Original languageGerman
Pages (from-to)773-779
Number of pages7
JournalNervenarzt
Volume70
Issue number9
DOIs
StatePublished - Sep 1 1999

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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