### Abstract

The often-used A(C)E model that decomposes phenotypic variance into parts due to additive genetic and environmental influences can be extended to a longitudinal model when the trait has been assessed at multiple occasions. This enables inference about the nature (e.g., genetic or environmental) of the covariance among the different measurement points. In the case that the measurement of the phenotype relies on self-report data (e.g., questionnaire data), often, aggregated scores (e.g., sum–scores) are used as a proxy for the phenotype. However, earlier research based on the univariate ACE model that concerns a single measurement occasion has shown that this can lead to an underestimation of heritability and that instead, one should prefer to model the raw item data by integrating an explicit measurement model into the analysis. This has, however, not been translated to the more complex longitudinal case. In this paper, we first present a latent state twin A(C)E model that combines the genetic twin model with an item response theory (IRT) model as well as its specification in a Bayesian framework. Two simulation studies were conducted to investigate 1) how large the bias is when sum–scores are used in the longitudinal A(C)E model and 2) if using the latent twin model can overcome the potential bias. Results of the first simulation study (e.g., AE model) demonstrated that using a sum–score approach leads to underestimated heritability estimates and biased covariance estimates. Surprisingly, the IRT approach also lead to bias, but to a much lesser degree. The amount of bias increased in the second simulation study (e.g., ACE model) under both frameworks, with the IRT approach still being the less biased approach. Since the bias was less severe under the IRT approach than under the sum–score approach and due to other advantages of latent variable modelling, we still advise researcher to adopt the IRT approach. We further illustrate differences between the traditional sum–score approach and the latent state twin A(C)E model by analyzing data of a two-wave twin study, consisting of the answers of 8,016 twins on a scale developed to measure social attitudes related to conservatism.

Original language | English (US) |
---|---|

Article number | 837 |

Journal | Frontiers in Genetics |

Volume | 10 |

Issue number | OCT |

DOIs | |

State | Published - Jan 1 2019 |

### Fingerprint

### All Science Journal Classification (ASJC) codes

- Molecular Medicine
- Genetics
- Genetics(clinical)

### Cite this

*Frontiers in Genetics*,

*10*(OCT), [837]. https://doi.org/10.3389/fgene.2019.00837

}

*Frontiers in Genetics*, vol. 10, no. OCT, 837. https://doi.org/10.3389/fgene.2019.00837

**Psychometric modelling of longitudinal genetically informative twin data.** / Schwabe, Inga; Gu, Zhengguo; Tijmstra, Jesper; Hatemi, Pete; Pohl, Steffi.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Psychometric modelling of longitudinal genetically informative twin data

AU - Schwabe, Inga

AU - Gu, Zhengguo

AU - Tijmstra, Jesper

AU - Hatemi, Pete

AU - Pohl, Steffi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The often-used A(C)E model that decomposes phenotypic variance into parts due to additive genetic and environmental influences can be extended to a longitudinal model when the trait has been assessed at multiple occasions. This enables inference about the nature (e.g., genetic or environmental) of the covariance among the different measurement points. In the case that the measurement of the phenotype relies on self-report data (e.g., questionnaire data), often, aggregated scores (e.g., sum–scores) are used as a proxy for the phenotype. However, earlier research based on the univariate ACE model that concerns a single measurement occasion has shown that this can lead to an underestimation of heritability and that instead, one should prefer to model the raw item data by integrating an explicit measurement model into the analysis. This has, however, not been translated to the more complex longitudinal case. In this paper, we first present a latent state twin A(C)E model that combines the genetic twin model with an item response theory (IRT) model as well as its specification in a Bayesian framework. Two simulation studies were conducted to investigate 1) how large the bias is when sum–scores are used in the longitudinal A(C)E model and 2) if using the latent twin model can overcome the potential bias. Results of the first simulation study (e.g., AE model) demonstrated that using a sum–score approach leads to underestimated heritability estimates and biased covariance estimates. Surprisingly, the IRT approach also lead to bias, but to a much lesser degree. The amount of bias increased in the second simulation study (e.g., ACE model) under both frameworks, with the IRT approach still being the less biased approach. Since the bias was less severe under the IRT approach than under the sum–score approach and due to other advantages of latent variable modelling, we still advise researcher to adopt the IRT approach. We further illustrate differences between the traditional sum–score approach and the latent state twin A(C)E model by analyzing data of a two-wave twin study, consisting of the answers of 8,016 twins on a scale developed to measure social attitudes related to conservatism.

AB - The often-used A(C)E model that decomposes phenotypic variance into parts due to additive genetic and environmental influences can be extended to a longitudinal model when the trait has been assessed at multiple occasions. This enables inference about the nature (e.g., genetic or environmental) of the covariance among the different measurement points. In the case that the measurement of the phenotype relies on self-report data (e.g., questionnaire data), often, aggregated scores (e.g., sum–scores) are used as a proxy for the phenotype. However, earlier research based on the univariate ACE model that concerns a single measurement occasion has shown that this can lead to an underestimation of heritability and that instead, one should prefer to model the raw item data by integrating an explicit measurement model into the analysis. This has, however, not been translated to the more complex longitudinal case. In this paper, we first present a latent state twin A(C)E model that combines the genetic twin model with an item response theory (IRT) model as well as its specification in a Bayesian framework. Two simulation studies were conducted to investigate 1) how large the bias is when sum–scores are used in the longitudinal A(C)E model and 2) if using the latent twin model can overcome the potential bias. Results of the first simulation study (e.g., AE model) demonstrated that using a sum–score approach leads to underestimated heritability estimates and biased covariance estimates. Surprisingly, the IRT approach also lead to bias, but to a much lesser degree. The amount of bias increased in the second simulation study (e.g., ACE model) under both frameworks, with the IRT approach still being the less biased approach. Since the bias was less severe under the IRT approach than under the sum–score approach and due to other advantages of latent variable modelling, we still advise researcher to adopt the IRT approach. We further illustrate differences between the traditional sum–score approach and the latent state twin A(C)E model by analyzing data of a two-wave twin study, consisting of the answers of 8,016 twins on a scale developed to measure social attitudes related to conservatism.

UR - http://www.scopus.com/inward/record.url?scp=85072779663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072779663&partnerID=8YFLogxK

U2 - 10.3389/fgene.2019.00837

DO - 10.3389/fgene.2019.00837

M3 - Article

C2 - 31681400

AN - SCOPUS:85072779663

VL - 10

JO - Frontiers in Genetics

JF - Frontiers in Genetics

SN - 1664-8021

IS - OCT

M1 - 837

ER -