Abstract
Study Objectives: Excessive daytime sleepiness (EDS) is a key symptom of obstructive sleep apnea (OSA). The Psychomotor Vigilance Task (PVT) has been suggested as an objective easy-to-use, inexpensive alternative to the Multiple Sleep Latency Test (MSLT) to measure EDS. In patients with OSA, physiological sleepiness, but not subjective EDS (Epworth Sleepiness Scale [ESS]), has been associated with increased levels of the sleep- inducing proinflammatory cytokine interleukin-6 (IL-6). The goal of this study was to assess the association of PVT with objectively measured sleepiness (MSLT) and subjectively measured sleepiness (ESS) and IL-6 levels in patients with OSA. Methods: We studied 58 untreated patients with OSA who underwent an 8-hour in-laboratory polysomnography for 4 consecutive nights. MSLT, PVT, and 24-hour serial profiles of IL-6 were assessed on the fourth day. PVT variables included number of lapses, mean reciprocal of the fastest 10% and slowest 10% reaction times, and median of 1/reaction time. ESS was assessed on day 1 of the study. Results: Higher ESS scores were significantly associated with greater number of lapses (β = .34, P = .02) and lower values of 1/RT (β = −.36, P = .01) and slowest 10% RTs (β = −.30, P = .04). No significant association was observed between PVT and MSLT, nor PVT and IL-6 levels. Conclusions: Our findings suggest that PVT is associated with subjectively assessed daytime sleepiness, but not with physiological sleepiness nor IL-6 levels in patients with OSA. It appears that ESS and PVT may be useful in predicting risks associated with impaired performance, such as traffic accidents, in patients with OSA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1049-1056 |
| Number of pages | 8 |
| Journal | Journal of Clinical Sleep Medicine |
| Volume | 13 |
| Issue number | 9 |
| DOIs | |
| State | Published - Jan 1 2017 |
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All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine
- Neurology
- Clinical Neurology
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Psychomotor vigilance test and its association with daytime sleepiness and inflammation in sleep apnea : Clinical implications. / Li, Yun; Vgontzas, Alexandros; Kritikou, Ilia; Fernandez-Mendoza, Julio; Basta, Maria; Pejovic, Slobodanka; Gaines, Jordan; Bixler, Edward O.
In: Journal of Clinical Sleep Medicine, Vol. 13, No. 9, 01.01.2017, p. 1049-1056.Research output: Contribution to journal › Article
TY - JOUR
T1 - Psychomotor vigilance test and its association with daytime sleepiness and inflammation in sleep apnea
T2 - Clinical implications
AU - Li, Yun
AU - Vgontzas, Alexandros
AU - Kritikou, Ilia
AU - Fernandez-Mendoza, Julio
AU - Basta, Maria
AU - Pejovic, Slobodanka
AU - Gaines, Jordan
AU - Bixler, Edward O.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Study Objectives: Excessive daytime sleepiness (EDS) is a key symptom of obstructive sleep apnea (OSA). The Psychomotor Vigilance Task (PVT) has been suggested as an objective easy-to-use, inexpensive alternative to the Multiple Sleep Latency Test (MSLT) to measure EDS. In patients with OSA, physiological sleepiness, but not subjective EDS (Epworth Sleepiness Scale [ESS]), has been associated with increased levels of the sleep- inducing proinflammatory cytokine interleukin-6 (IL-6). The goal of this study was to assess the association of PVT with objectively measured sleepiness (MSLT) and subjectively measured sleepiness (ESS) and IL-6 levels in patients with OSA. Methods: We studied 58 untreated patients with OSA who underwent an 8-hour in-laboratory polysomnography for 4 consecutive nights. MSLT, PVT, and 24-hour serial profiles of IL-6 were assessed on the fourth day. PVT variables included number of lapses, mean reciprocal of the fastest 10% and slowest 10% reaction times, and median of 1/reaction time. ESS was assessed on day 1 of the study. Results: Higher ESS scores were significantly associated with greater number of lapses (β = .34, P = .02) and lower values of 1/RT (β = −.36, P = .01) and slowest 10% RTs (β = −.30, P = .04). No significant association was observed between PVT and MSLT, nor PVT and IL-6 levels. Conclusions: Our findings suggest that PVT is associated with subjectively assessed daytime sleepiness, but not with physiological sleepiness nor IL-6 levels in patients with OSA. It appears that ESS and PVT may be useful in predicting risks associated with impaired performance, such as traffic accidents, in patients with OSA.
AB - Study Objectives: Excessive daytime sleepiness (EDS) is a key symptom of obstructive sleep apnea (OSA). The Psychomotor Vigilance Task (PVT) has been suggested as an objective easy-to-use, inexpensive alternative to the Multiple Sleep Latency Test (MSLT) to measure EDS. In patients with OSA, physiological sleepiness, but not subjective EDS (Epworth Sleepiness Scale [ESS]), has been associated with increased levels of the sleep- inducing proinflammatory cytokine interleukin-6 (IL-6). The goal of this study was to assess the association of PVT with objectively measured sleepiness (MSLT) and subjectively measured sleepiness (ESS) and IL-6 levels in patients with OSA. Methods: We studied 58 untreated patients with OSA who underwent an 8-hour in-laboratory polysomnography for 4 consecutive nights. MSLT, PVT, and 24-hour serial profiles of IL-6 were assessed on the fourth day. PVT variables included number of lapses, mean reciprocal of the fastest 10% and slowest 10% reaction times, and median of 1/reaction time. ESS was assessed on day 1 of the study. Results: Higher ESS scores were significantly associated with greater number of lapses (β = .34, P = .02) and lower values of 1/RT (β = −.36, P = .01) and slowest 10% RTs (β = −.30, P = .04). No significant association was observed between PVT and MSLT, nor PVT and IL-6 levels. Conclusions: Our findings suggest that PVT is associated with subjectively assessed daytime sleepiness, but not with physiological sleepiness nor IL-6 levels in patients with OSA. It appears that ESS and PVT may be useful in predicting risks associated with impaired performance, such as traffic accidents, in patients with OSA.
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U2 - 10.5664/jcsm.6720
DO - 10.5664/jcsm.6720
M3 - Article
C2 - 28728622
AN - SCOPUS:85030677736
VL - 13
SP - 1049
EP - 1056
JO - Journal of Clinical Sleep Medicine
JF - Journal of Clinical Sleep Medicine
SN - 1550-9389
IS - 9
ER -