Puberty in girls: Correlation of serum levels of gonadotropins, prolactin, androgens, estrogens, and progestins with physical changes

Peter Lee, Theodore Xenakis, Jane Winer, Sandra Matsenbaugh

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Twenty-seven girls aged 8 to 18 were studied in a longitudinal prospective fashion. Serum samples were collected at 6 month intervals up to 4 years and radioassayed for hormones of pituitary, ovarian, and adrenal origin. A progressive elevation of luteinizing hormone (LH), folliclestimulating hormone (FSH), estradiol (E2), dehydroepiandrosterone (DHA), and androstenedione (A4) occurred during puberty and continued until menarche. The onset of puberty occurred concomitantly with an elevation of estrone (E2) dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), and 17-hydroxyprogesterone (17- OH-P). Prolactin (Prol) and progesterone (Prog) concentrations did not change during puberty until after menarche. After menarche, levels of LH and FSH were comparable with menstruating adult females. Concentrations of E2 and Prog were lower during the second half of the cycle among most regularly menstruating subjects than expected during the luteal phase. LH and Prog levels indirectly suggest that ovulation occurs in a few girls within months after menarche.

Original languageEnglish (US)
Pages (from-to)775-784
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Volume43
Issue number4
DOIs
StatePublished - Jan 1 1976

Fingerprint

Menarche
Progestins
Puberty
Luteinizing Hormone
Gonadotropins
Prolactin
Androgens
Progesterone
Estrogens
Dehydroepiandrosterone
Serum
Hormones
17-alpha-Hydroxyprogesterone
Dehydroepiandrosterone Sulfate
Pituitary Hormones
Androstenedione
Estrone
Luteal Phase
Estradiol
Ovulation

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

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abstract = "Twenty-seven girls aged 8 to 18 were studied in a longitudinal prospective fashion. Serum samples were collected at 6 month intervals up to 4 years and radioassayed for hormones of pituitary, ovarian, and adrenal origin. A progressive elevation of luteinizing hormone (LH), folliclestimulating hormone (FSH), estradiol (E2), dehydroepiandrosterone (DHA), and androstenedione (A4) occurred during puberty and continued until menarche. The onset of puberty occurred concomitantly with an elevation of estrone (E2) dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), and 17-hydroxyprogesterone (17- OH-P). Prolactin (Prol) and progesterone (Prog) concentrations did not change during puberty until after menarche. After menarche, levels of LH and FSH were comparable with menstruating adult females. Concentrations of E2 and Prog were lower during the second half of the cycle among most regularly menstruating subjects than expected during the luteal phase. LH and Prog levels indirectly suggest that ovulation occurs in a few girls within months after menarche.",
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Puberty in girls : Correlation of serum levels of gonadotropins, prolactin, androgens, estrogens, and progestins with physical changes. / Lee, Peter; Xenakis, Theodore; Winer, Jane; Matsenbaugh, Sandra.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 43, No. 4, 01.01.1976, p. 775-784.

Research output: Contribution to journalArticle

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