Public health consequences of macrolide use in food animals: A deterministic risk assessment

H. Scott Hurd, Stephanie Doores, Dermot Hayes, Alan Mathew, John Maurer, Peter Silley, Randall S. Singer, Ronald N. Jones

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The potential impact on human health from antibiotic-resistant bacteria selected by use of antibiotics in food animals has resulted in many reports and recommended actions. The U.S. Food and Drug Administration Center for Veterinary Medicine has issued Guidance Document 152, which advises veterinary drug sponsors of one potential process for conducting a qualitative risk assessment of drug use in food animals. Using this guideline, we developed a deterministic model to assess the risk from two macrolide antibiotics, tylosin and tilmicosin. The scope of modeling included all label claim uses of both macrolides in poultry, swine, and beef cattle. The Guidance Document was followed to define the hazard, which is illness (i) caused by foodborne bacteria with a resistance determinant, (ii) attributed to a specified animal-derived meat commodity, and (iii) treated with a human use drug of the same class. Risk was defined as the probability of this hazard combined with the consequence of treatment failure due to resistant Campylobacter spp. or Enterococcus faecium. A binomial event model was applied to estimate the annual risk for the U.S. general population. Parameters were derived from industry drug use surveys, scientific literature, medical guidelines, and government documents. This unique farm-to-patient risk assessment demonstrated that use of tylosin and tilmicosin in food animals presents a very low risk of human treatment failure, with an approximate annual probability of less than 1 in 10 million Campylobacter-derived and approximately 1 in 3 billion E. faecium-derived risk.

Original languageEnglish (US)
Pages (from-to)980-992
Number of pages13
JournalJournal of Food Protection
Volume67
Issue number5
DOIs
StatePublished - May 2004

Fingerprint

deterministic risk assessment
macrolides
Macrolides
food animals
public health
Public Health
Food
Tylosin
Enterococcus faecium
tylosin
Campylobacter
Anti-Bacterial Agents
Treatment Failure
qualitative risk assessment
antibiotics
macrolide antibiotics
Veterinary Drugs
Guidelines
Bacteria
Literature

All Science Journal Classification (ASJC) codes

  • Food Science
  • Microbiology

Cite this

Hurd, H. S., Doores, S., Hayes, D., Mathew, A., Maurer, J., Silley, P., ... Jones, R. N. (2004). Public health consequences of macrolide use in food animals: A deterministic risk assessment. Journal of Food Protection, 67(5), 980-992. https://doi.org/10.4315/0362-028X-67.5.980
Hurd, H. Scott ; Doores, Stephanie ; Hayes, Dermot ; Mathew, Alan ; Maurer, John ; Silley, Peter ; Singer, Randall S. ; Jones, Ronald N. / Public health consequences of macrolide use in food animals : A deterministic risk assessment. In: Journal of Food Protection. 2004 ; Vol. 67, No. 5. pp. 980-992.
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Hurd, HS, Doores, S, Hayes, D, Mathew, A, Maurer, J, Silley, P, Singer, RS & Jones, RN 2004, 'Public health consequences of macrolide use in food animals: A deterministic risk assessment', Journal of Food Protection, vol. 67, no. 5, pp. 980-992. https://doi.org/10.4315/0362-028X-67.5.980

Public health consequences of macrolide use in food animals : A deterministic risk assessment. / Hurd, H. Scott; Doores, Stephanie; Hayes, Dermot; Mathew, Alan; Maurer, John; Silley, Peter; Singer, Randall S.; Jones, Ronald N.

In: Journal of Food Protection, Vol. 67, No. 5, 05.2004, p. 980-992.

Research output: Contribution to journalArticle

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