Pulmonary crystal-storing histiocytosis diagnosed by computed tomography-guided fine-needle aspiration

William U. Todd, Joseph J. Drabick, Michael G. Benninghoff, Elizabeth E. Frauenhoffer, Dani S. Zander

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Crystal-storing histiocytosis (CSH) is a rare process most often occurring in conjunction with an underlying hematopoietic neoplasm, usually multiple myeloma or low-grade B-cell lymphoma. We report the first case of pulmonary CSH diagnosed by fineneedle aspiration biopsy. A patient with a history of urothelial carcinoma developed a lung nodule, which was evaluated by fine-needle aspiration biopsy. Cytologic examination revealed macrophages with abundant cytoplasmic crystals diagnostic of CSH. Based on this cytologic interpretation, additional clinical laboratory evaluation was pursued and revealed a previously unknown monoclonal serum protein. CSH must be differentiated from other non-neoplastic and neoplastic lesions and when diagnosed, should trigger a search for an underlying lymphoproliferative disorder.

Original languageEnglish (US)
Pages (from-to)274-278
Number of pages5
JournalDiagnostic Cytopathology
Issue number4
StatePublished - Apr 2010

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology


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