Pulmonary host defenses. II. Interaction of respiratory antibodies with Pseudomonas aeruginosa and alveolar macrophages

Herbert Reynolds, R. E. Thompson

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The opsonic properties of immune bronchial secretions and IgA and IgG antibodies separated from them were assessed in an in vitro alveolar macrophage system for their effect on phagocytosis and intracellular killing of P. aeruginosa. Although IgA and IgG antibodies had specific agglutinative activity, IgG had superior opsonizing properties when compared with IgA. Also, it seemed to be the principal opsonin in normal respiratory secretions. Immune IgG whether isolated from bronchial fluid or serum was indistinguishable in its opsonic activity; however, the intact IgG molecule was required for optimal function. Opsonins specifically facilitated the phagocytosis of bacteria by macrophages; once ingestion had occurred, intracellular killing of Pseudomonas organisms was rapid and seemingly unrelated to the immune status of the opsonins.

Original languageEnglish (US)
Pages (from-to)369-380
Number of pages12
JournalJournal of Immunology
Volume111
Issue number2
StatePublished - Dec 1 1973

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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