Pulmonary surfactant: An immunological perspective

Zissis Chroneos, Zvjezdana Sever-Chroneos, Virginia Shepherd

Research output: Contribution to journalReview article

111 Citations (Scopus)

Abstract

Pulmonary surfactant has two crucial roles in respiratory function; first, as a biophysical entity it reduces surface tension at the air water interface, facilitating gas exchange and alveolar stability during breathing, and, second, as an innate component of the lung's immune system it helps maintain sterility and balance immune reactions in the distal airways. Pulmonary surfactant consists of 90% lipids and 10% protein. There are four surfactant proteins named SP-A, SP-B, SP-C, and SP-D; their distinct interactions with surfactant phospholipids are necessary for the ultra-structural organization, stability, metabolism, and lowering of surface tension. In addition, SP-A and SP-D bind pathogens, inflict damage to microbial membranes, and regulate microbial phagocytosis and activation or deactivation of inflammatory responses by alveolar macrophages. SP-A and SP-D, also known as pulmonary collectins, mediate microbial phagocytosis via SP-A and SP-D receptors and the coordinated induction of other innate receptors. Several receptors (SP-R210, CD91/calreticulin, SIRPα, and toll-like receptors) mediate the immunological functions of SP-A and SP-D. However, accumulating evidence indicate that SP-B and SP-C and one or more lipid constituents of surfactant share similar immuno-regulatory properties as SP-A and SP-D. The present review discusses current knowledge on the interaction of surfactant with lung innate host defense.

Original languageEnglish (US)
Pages (from-to)13-26
Number of pages14
JournalCellular Physiology and Biochemistry
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2010

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Pulmonary Surfactant-Associated Protein D
Pulmonary Surfactants
Surface-Active Agents
Surface Tension
Phagocytosis
Lung
Collectins
Pulmonary Surfactant-Associated Protein A
Calreticulin
Lipids
Toll-Like Receptors
Alveolar Macrophages
Infertility
Immune System
Phospholipids
Respiration
Gases
Air
Membranes
Water

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

Chroneos, Zissis ; Sever-Chroneos, Zvjezdana ; Shepherd, Virginia. / Pulmonary surfactant : An immunological perspective. In: Cellular Physiology and Biochemistry. 2010 ; Vol. 25, No. 1. pp. 13-26.
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Pulmonary surfactant : An immunological perspective. / Chroneos, Zissis; Sever-Chroneos, Zvjezdana; Shepherd, Virginia.

In: Cellular Physiology and Biochemistry, Vol. 25, No. 1, 01.01.2010, p. 13-26.

Research output: Contribution to journalReview article

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