Pulsatile perfusion during cardiopulmonary bypass procedures in neonates, infants, and small children

Alan R. Rider, Robert S. Schreiner, Akif Ündar

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Multiple factors influence the outcome of cardiopulmonary bypass (CPB) procedures in pediatric patients with congenital heart defects. The benefit of pulsatile over nonpulsatile perfusion is one such factor that continues to be widely debated among researchers, perfusionists, and surgeons. However, by accurately measuring pulsatile flow in terms of energy equivalent pressure and surplus hemodynamic energy, pulsatile perfusion is clearly seen to replicate the physiologic heart in a manner unparalleled by nonpulsatile perfusion. Studied benefits of pulsatile perfusion in pediatric patients include increased vital organ blood flow and improvement in postoperative recovery. Also, the components of the extracorporeal circuit used in CPB are directly related to pulsatility and have a profound effect on hemodynamics in the circuit and the patient. Therefore, pulsatility and surplus hemodynamic energy delivery to the patient can be maximized by choosing the best performing heart-pumps, oxygenators, arterial filters, and cannulae. Furthermore, in using the most optimal circuit components available, the CPB procedure under pulsatile perfusion can proceed efficiently. Currently, the outcomes resulting from pulsatile perfusion in pediatric and adult patients, as well as animal models, are well documented. However, more multilaboratory efforts are necessary to understand and further validate the benefits of pulsatile perfusion in pediatric patients.

Original languageEnglish (US)
Pages (from-to)706-709
Number of pages4
JournalASAIO Journal
Volume53
Issue number6
DOIs
StatePublished - Nov 1 2007

Fingerprint

Pulsatile Flow
Pediatrics
Cardiopulmonary Bypass
Hemodynamics
Newborn Infant
Networks (circuits)
Oxygenators
Pulsatile flow
Perfusion
Animals
Blood
Congenital Heart Defects
Pumps
Recovery
Defects
Animal Models
Research Personnel
Pressure

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

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Pulsatile perfusion during cardiopulmonary bypass procedures in neonates, infants, and small children. / Rider, Alan R.; Schreiner, Robert S.; Ündar, Akif.

In: ASAIO Journal, Vol. 53, No. 6, 01.11.2007, p. 706-709.

Research output: Contribution to journalArticle

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