Pulse Voltammetry in Single Cells Using Platinum Microelectrodes

Ta Kung Chen, Yau Yi Lau, Danny K.Y. Wong, Andrew G. Ewing

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple pulse voltammetry at platinum microelectrodes Is described for Intracellular measurements. In this technique, a sequence of three potential pulses Is used for each current point measured. This pulse sequence provides a fixed cathodic activation potential and a fixed anodic cleaning potential before a varying detection potential, at which the current Is measured. Voltammetrlc Information Is obtained by ramping the detection potential stepwise through the potential range of interest. The multiple pulse voltammetry technique has been applied to the study of the oxidation of potassium ferrocyanlde, glucose, and several catechols at platinum microdisk electrodes. In addition, this technique has been applied at ultrasmall platinum ring electrodes to reduce electrode fouling during Intracellular voltammetry. In these In vivo experiments, the electrode response Is degraded by only 30% after 40 mln of Intracellular voHammetry.

Original languageEnglish (US)
Pages (from-to)1264-1268
Number of pages5
JournalAnalytical Chemistry
Volume64
Issue number11
DOIs
StatePublished - Jun 1992

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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