Pulsed Focused Ultrasound Treatment of Muscle Mitigates Paralysis-Induced Bone Loss in the Adjacent Bone: A Study in a Mouse Model

Sandra L. Poliachik, Tatiana D. Khokhlova, Yak Nam Wang, Julianna C. Simon, Michael R. Bailey

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Bone loss can result from bed rest, space flight, spinal cord injury or age-related hormonal changes. Current bone loss mitigation techniques include pharmaceutical interventions, exercise, pulsed ultrasound targeted to bone and whole body vibration. In this study, we attempted to mitigate paralysis-induced bone loss by applying focused ultrasound to the midbelly of a paralyzed muscle. We employed a mouse model of disuse that uses onabotulinumtoxinA-induced paralysis, which causes rapid bone loss in 5 d. A focused 2 MHz transducer applied pulsed exposures with pulse repetition frequency mimicking that of motor neuron firing during walking (80 Hz), standing (20 Hz), or the standard pulsed ultrasound frequency used in fracture healing (1 kHz). Exposures were applied daily to calf muscle for 4 consecutive d. Trabecular bone changes were characterized using micro-computed tomography. Our results indicated that application of certain focused pulsed ultrasound parameters was able to mitigate some of the paralysis-induced bone loss.

Original languageEnglish (US)
Pages (from-to)2113-2124
Number of pages12
JournalUltrasound in Medicine and Biology
Volume40
Issue number9
DOIs
StatePublished - Sep 2014

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

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