Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma

Sergey Malchenko, Elisabeth A. Seftor, Yuri Nikolsky, Susan L. Hasegawa, Sean Kuo, Jeff W. Stevens, Stas Poyarkov, Tatiana Nikolskaya, Tamara Kucaba, Min Wang, Hakim Abdulkawy, Thomas Casavant, Jose Morcuende, Joseph Buckwalter, Raymond Hohl, Barry Deyoung, Kemp Kernstine, Maria De Fatima Bonaldo, Mary J.C. Hendrix, Marcelo B. Soares & 1 others Vera Maria F.C. Soares

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90 of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of multifunctional genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.

Original languageEnglish (US)
Article number820254
JournalSarcoma
Volume2012
DOIs
StatePublished - Mar 16 2012

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Chondrosarcoma
Neoplasm Metastasis
Lung
Gene Expression Profiling
Transcriptome
Macrophages
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Malchenko, S., Seftor, E. A., Nikolsky, Y., Hasegawa, S. L., Kuo, S., Stevens, J. W., ... Soares, V. M. F. C. (2012). Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma. Sarcoma, 2012, [820254]. https://doi.org/10.1155/2012/820254
Malchenko, Sergey ; Seftor, Elisabeth A. ; Nikolsky, Yuri ; Hasegawa, Susan L. ; Kuo, Sean ; Stevens, Jeff W. ; Poyarkov, Stas ; Nikolskaya, Tatiana ; Kucaba, Tamara ; Wang, Min ; Abdulkawy, Hakim ; Casavant, Thomas ; Morcuende, Jose ; Buckwalter, Joseph ; Hohl, Raymond ; Deyoung, Barry ; Kernstine, Kemp ; Bonaldo, Maria De Fatima ; Hendrix, Mary J.C. ; Soares, Marcelo B. ; Soares, Vera Maria F.C. / Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma. In: Sarcoma. 2012 ; Vol. 2012.
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abstract = "Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90 of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of multifunctional genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.",
author = "Sergey Malchenko and Seftor, {Elisabeth A.} and Yuri Nikolsky and Hasegawa, {Susan L.} and Sean Kuo and Stevens, {Jeff W.} and Stas Poyarkov and Tatiana Nikolskaya and Tamara Kucaba and Min Wang and Hakim Abdulkawy and Thomas Casavant and Jose Morcuende and Joseph Buckwalter and Raymond Hohl and Barry Deyoung and Kemp Kernstine and Bonaldo, {Maria De Fatima} and Hendrix, {Mary J.C.} and Soares, {Marcelo B.} and Soares, {Vera Maria F.C.}",
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Malchenko, S, Seftor, EA, Nikolsky, Y, Hasegawa, SL, Kuo, S, Stevens, JW, Poyarkov, S, Nikolskaya, T, Kucaba, T, Wang, M, Abdulkawy, H, Casavant, T, Morcuende, J, Buckwalter, J, Hohl, R, Deyoung, B, Kernstine, K, Bonaldo, MDF, Hendrix, MJC, Soares, MB & Soares, VMFC 2012, 'Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma', Sarcoma, vol. 2012, 820254. https://doi.org/10.1155/2012/820254

Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma. / Malchenko, Sergey; Seftor, Elisabeth A.; Nikolsky, Yuri; Hasegawa, Susan L.; Kuo, Sean; Stevens, Jeff W.; Poyarkov, Stas; Nikolskaya, Tatiana; Kucaba, Tamara; Wang, Min; Abdulkawy, Hakim; Casavant, Thomas; Morcuende, Jose; Buckwalter, Joseph; Hohl, Raymond; Deyoung, Barry; Kernstine, Kemp; Bonaldo, Maria De Fatima; Hendrix, Mary J.C.; Soares, Marcelo B.; Soares, Vera Maria F.C.

In: Sarcoma, Vol. 2012, 820254, 16.03.2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma

AU - Malchenko, Sergey

AU - Seftor, Elisabeth A.

AU - Nikolsky, Yuri

AU - Hasegawa, Susan L.

AU - Kuo, Sean

AU - Stevens, Jeff W.

AU - Poyarkov, Stas

AU - Nikolskaya, Tatiana

AU - Kucaba, Tamara

AU - Wang, Min

AU - Abdulkawy, Hakim

AU - Casavant, Thomas

AU - Morcuende, Jose

AU - Buckwalter, Joseph

AU - Hohl, Raymond

AU - Deyoung, Barry

AU - Kernstine, Kemp

AU - Bonaldo, Maria De Fatima

AU - Hendrix, Mary J.C.

AU - Soares, Marcelo B.

AU - Soares, Vera Maria F.C.

PY - 2012/3/16

Y1 - 2012/3/16

N2 - Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90 of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of multifunctional genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.

AB - Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90 of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of multifunctional genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.

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M3 - Article

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JO - Sarcoma

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Malchenko S, Seftor EA, Nikolsky Y, Hasegawa SL, Kuo S, Stevens JW et al. Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma. Sarcoma. 2012 Mar 16;2012. 820254. https://doi.org/10.1155/2012/820254