Pyoderma gangrenosum-like ulcer in a patient with large granular lymphocytic leukemia

Klaus Helm, Margot S. Peters, Ayalew Tefferi, Kristin M. Leiferman

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Large granular lymphocytic leukemia refers to a clonal expansion of lymphocytes that have abundant cytoplasm and azurophilic granules. The disease is characterized clinically by chronic neutropenia and it may be associated with recurrent pyogenic infections. Except for these infections, cutaneous manifestations of this disease have not been well characterized. We describe a patient with large granular lymphocytic leukemia, which was confirmed by molecular genetics studies, who had a pyoderma gangrenosum-like ulcer on his leg. Results of an evaluation of the histologic characteristics and the leukocytic immunophenotype of a skin biopsy specimen from the ulcer demonstrated large granular lymphocytes within the blood vessels. Cutaneous ulceration may be a manifestation of large granular lymphocytic leukemia, and this disease should be considered when diagnosing patients with otherwise unexplained pyoderma gangrenosum-like ulcers of the skin.

Original languageEnglish (US)
Pages (from-to)868-871
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume27
Issue number5
DOIs
StatePublished - Jan 1 1992

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Large Granular Lymphocytic Leukemia
Pyoderma Gangrenosum
Ulcer
Lymphocytes
Skin Ulcer
Skin Manifestations
Skin
Leg Ulcer
Infection
Neutropenia
Skin Diseases
Blood Vessels
Molecular Biology
Cytoplasm
Biopsy

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Helm, Klaus ; Peters, Margot S. ; Tefferi, Ayalew ; Leiferman, Kristin M. / Pyoderma gangrenosum-like ulcer in a patient with large granular lymphocytic leukemia. In: Journal of the American Academy of Dermatology. 1992 ; Vol. 27, No. 5. pp. 868-871.
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Pyoderma gangrenosum-like ulcer in a patient with large granular lymphocytic leukemia. / Helm, Klaus; Peters, Margot S.; Tefferi, Ayalew; Leiferman, Kristin M.

In: Journal of the American Academy of Dermatology, Vol. 27, No. 5, 01.01.1992, p. 868-871.

Research output: Contribution to journalArticle

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AB - Large granular lymphocytic leukemia refers to a clonal expansion of lymphocytes that have abundant cytoplasm and azurophilic granules. The disease is characterized clinically by chronic neutropenia and it may be associated with recurrent pyogenic infections. Except for these infections, cutaneous manifestations of this disease have not been well characterized. We describe a patient with large granular lymphocytic leukemia, which was confirmed by molecular genetics studies, who had a pyoderma gangrenosum-like ulcer on his leg. Results of an evaluation of the histologic characteristics and the leukocytic immunophenotype of a skin biopsy specimen from the ulcer demonstrated large granular lymphocytes within the blood vessels. Cutaneous ulceration may be a manifestation of large granular lymphocytic leukemia, and this disease should be considered when diagnosing patients with otherwise unexplained pyoderma gangrenosum-like ulcers of the skin.

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