QTLs for general cognitive ability in children: DNA pooling for chromosome 22

L. Hill, P. Asherson, D. Ball, I. Craig, J. Daniels, T. Eley, B. Freeman, T. Ninomiya, P. Fisher, D. Turic, N. Williams, M. Chorney, K. Chorney, D. Lubinski, C. Benbow, L. A. Thompson, D. K. Detterman, M. J. Owen, P. McGuffin, R. Plomin

Research output: Contribution to journalArticle

Abstract

General cognitive ability, often indexed by IQ tests, is one of the most highly heritable quantitative behavioral traits relevant to cognitive neuroscience. The IQ QTL Project uses an allelic association strategy to focus on high ability rather than disability and a more systematic approach to association using a dense genome-wide map of markers and DNA pooling. The purpose of the present study was to apply DNA pooling to 75 markers on chromosome 22 (average interval 1 cM) for an original high IQ sample (N = 51, average IQ = 136) and an average IQ control group (N = 51, average IQ = 103). Tentative QTL associations, as indexed by delta-AIP, in the original sample are subjected to replication, again using DNA pooling, with an extremely high IQ group (N = 52, IQ >160) and an independent control group (N = 50, average IQ = 101). Using a lenient criterion (delta-AIP > 0.2), 13 markers of interest were identified in the original sample; DNA pooling with these markers is underway in the replication sample. Markers that survive replication will then be individually genotyped for all subjects, enabling comparisons with the pooled results. This research demonstrates the usefulness of DNA pooling for a systematic genome scan in the analysis of complex quantitative traits.

Original languageEnglish (US)
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume81
Issue number6
StatePublished - Nov 6 1998

Fingerprint

Chromosomes, Human, Pair 22
Aptitude
DNA
Heritable Quantitative Trait
Genome
Control Groups
Genetic Markers
Research

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Hill, L., Asherson, P., Ball, D., Craig, I., Daniels, J., Eley, T., ... Plomin, R. (1998). QTLs for general cognitive ability in children: DNA pooling for chromosome 22. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(6).
Hill, L. ; Asherson, P. ; Ball, D. ; Craig, I. ; Daniels, J. ; Eley, T. ; Freeman, B. ; Ninomiya, T. ; Fisher, P. ; Turic, D. ; Williams, N. ; Chorney, M. ; Chorney, K. ; Lubinski, D. ; Benbow, C. ; Thompson, L. A. ; Detterman, D. K. ; Owen, M. J. ; McGuffin, P. ; Plomin, R. / QTLs for general cognitive ability in children : DNA pooling for chromosome 22. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 1998 ; Vol. 81, No. 6.
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Hill, L, Asherson, P, Ball, D, Craig, I, Daniels, J, Eley, T, Freeman, B, Ninomiya, T, Fisher, P, Turic, D, Williams, N, Chorney, M, Chorney, K, Lubinski, D, Benbow, C, Thompson, LA, Detterman, DK, Owen, MJ, McGuffin, P & Plomin, R 1998, 'QTLs for general cognitive ability in children: DNA pooling for chromosome 22', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 81, no. 6.

QTLs for general cognitive ability in children : DNA pooling for chromosome 22. / Hill, L.; Asherson, P.; Ball, D.; Craig, I.; Daniels, J.; Eley, T.; Freeman, B.; Ninomiya, T.; Fisher, P.; Turic, D.; Williams, N.; Chorney, M.; Chorney, K.; Lubinski, D.; Benbow, C.; Thompson, L. A.; Detterman, D. K.; Owen, M. J.; McGuffin, P.; Plomin, R.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 81, No. 6, 06.11.1998.

Research output: Contribution to journalArticle

TY - JOUR

T1 - QTLs for general cognitive ability in children

T2 - DNA pooling for chromosome 22

AU - Hill, L.

AU - Asherson, P.

AU - Ball, D.

AU - Craig, I.

AU - Daniels, J.

AU - Eley, T.

AU - Freeman, B.

AU - Ninomiya, T.

AU - Fisher, P.

AU - Turic, D.

AU - Williams, N.

AU - Chorney, M.

AU - Chorney, K.

AU - Lubinski, D.

AU - Benbow, C.

AU - Thompson, L. A.

AU - Detterman, D. K.

AU - Owen, M. J.

AU - McGuffin, P.

AU - Plomin, R.

PY - 1998/11/6

Y1 - 1998/11/6

N2 - General cognitive ability, often indexed by IQ tests, is one of the most highly heritable quantitative behavioral traits relevant to cognitive neuroscience. The IQ QTL Project uses an allelic association strategy to focus on high ability rather than disability and a more systematic approach to association using a dense genome-wide map of markers and DNA pooling. The purpose of the present study was to apply DNA pooling to 75 markers on chromosome 22 (average interval 1 cM) for an original high IQ sample (N = 51, average IQ = 136) and an average IQ control group (N = 51, average IQ = 103). Tentative QTL associations, as indexed by delta-AIP, in the original sample are subjected to replication, again using DNA pooling, with an extremely high IQ group (N = 52, IQ >160) and an independent control group (N = 50, average IQ = 101). Using a lenient criterion (delta-AIP > 0.2), 13 markers of interest were identified in the original sample; DNA pooling with these markers is underway in the replication sample. Markers that survive replication will then be individually genotyped for all subjects, enabling comparisons with the pooled results. This research demonstrates the usefulness of DNA pooling for a systematic genome scan in the analysis of complex quantitative traits.

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