Quality of evidence in drug compendia supporting off-label use of typical and atypical antipsychotic medications

Richard P. Paczynski, G. Caleb Alexander, Vernon M. Chinchilli, Stefan P. Kruszewski

Research output: Contribution to journalArticle

7 Scopus citations


Public and private payers use drug compendia to make coverage determinations, yet the quality of evidence they contain has received little scrutiny. We examined compendia citations regarding antipsychotic drugs, an important drug class given their substantial costs and widespread use. Nearly three-fold as many off-label indications were recommended for atypical as for typical agents, a difference that did not appear to be due to differences in quality of evidence for typical and atypical off-label indications. Given the important role that compendia play in evidence synthesis, coverage decisions, and ultimately, prescription utilization, these data suggest greater efforts are needed to improve the quality of evidence and transparency of evidence evaluations compendia contain.

Original languageEnglish (US)
Pages (from-to)137-146
Number of pages10
JournalInternational Journal of Risk and Safety in Medicine
Issue number3
StatePublished - Oct 1 2012


All Science Journal Classification (ASJC) codes

  • Health Policy
  • Public Health, Environmental and Occupational Health

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