Quality of life in ALS is maintained as physical function declines

R. A. Robbins, Zachary Simmons, B. A. Bremer, S. M. Walsh, S. Fischer

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Objectives: To study patients with ALS to determine how physical function, quality of life (QOL), and spirituality or religiousness change over time, and what relationship these changes have to one another. Methods: Sixty patients with ALS were studied prospectively. They were assessed at baseline, 3 months, and 6 months, using questionnaires designed to measure general quality of life (McGill Quality of Life questionnaire), religiosity (Idler Index of Religiosity), ALS-specific health-related quality of life (SIP/ALS-19), and ALS-specific function (ALS functional rating scale). Results: A two-way repeated measures multivariate analysis of variance revealed that both the passage of time and the specific QOL scales used were factors in predicting patient quality of life (F[1, 59]= 9.87, p < 0.003 and F[3, 177]= 16.90, p < 0.001) Despite a progressive decline in physical function as measured by the ALS-specific function score, the genera] QOL and religiosity scores changed little. In contrast, the ALS-specific health-related QOL score declined in parallel with the ALS-specific function score. Conclusions: QOL in patients with ALS appears to be independent of physical function, which agrees with a previous cross-sectional study. The ALS-specific health-related QOL score is primarily a measure of physical function. QOL instruments that assess spiritual, religious, and psychological factors produce different results than those obtained using measures of physical function alone.

Original languageEnglish (US)
Pages (from-to)442-444
Number of pages3
JournalNeurology
Volume56
Issue number4
DOIs
StatePublished - Feb 27 2001

Fingerprint

Quality of Life
Spirituality
Analysis of Variance
Multivariate Analysis
Cross-Sectional Studies
Psychology

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Robbins, R. A., Simmons, Z., Bremer, B. A., Walsh, S. M., & Fischer, S. (2001). Quality of life in ALS is maintained as physical function declines. Neurology, 56(4), 442-444. https://doi.org/10.1212/WNL.56.4.442
Robbins, R. A. ; Simmons, Zachary ; Bremer, B. A. ; Walsh, S. M. ; Fischer, S. / Quality of life in ALS is maintained as physical function declines. In: Neurology. 2001 ; Vol. 56, No. 4. pp. 442-444.
@article{64e36c0edeba4e4db02d61693775f016,
title = "Quality of life in ALS is maintained as physical function declines",
abstract = "Objectives: To study patients with ALS to determine how physical function, quality of life (QOL), and spirituality or religiousness change over time, and what relationship these changes have to one another. Methods: Sixty patients with ALS were studied prospectively. They were assessed at baseline, 3 months, and 6 months, using questionnaires designed to measure general quality of life (McGill Quality of Life questionnaire), religiosity (Idler Index of Religiosity), ALS-specific health-related quality of life (SIP/ALS-19), and ALS-specific function (ALS functional rating scale). Results: A two-way repeated measures multivariate analysis of variance revealed that both the passage of time and the specific QOL scales used were factors in predicting patient quality of life (F[1, 59]= 9.87, p < 0.003 and F[3, 177]= 16.90, p < 0.001) Despite a progressive decline in physical function as measured by the ALS-specific function score, the genera] QOL and religiosity scores changed little. In contrast, the ALS-specific health-related QOL score declined in parallel with the ALS-specific function score. Conclusions: QOL in patients with ALS appears to be independent of physical function, which agrees with a previous cross-sectional study. The ALS-specific health-related QOL score is primarily a measure of physical function. QOL instruments that assess spiritual, religious, and psychological factors produce different results than those obtained using measures of physical function alone.",
author = "Robbins, {R. A.} and Zachary Simmons and Bremer, {B. A.} and Walsh, {S. M.} and S. Fischer",
year = "2001",
month = "2",
day = "27",
doi = "10.1212/WNL.56.4.442",
language = "English (US)",
volume = "56",
pages = "442--444",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

Robbins, RA, Simmons, Z, Bremer, BA, Walsh, SM & Fischer, S 2001, 'Quality of life in ALS is maintained as physical function declines', Neurology, vol. 56, no. 4, pp. 442-444. https://doi.org/10.1212/WNL.56.4.442

Quality of life in ALS is maintained as physical function declines. / Robbins, R. A.; Simmons, Zachary; Bremer, B. A.; Walsh, S. M.; Fischer, S.

In: Neurology, Vol. 56, No. 4, 27.02.2001, p. 442-444.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Quality of life in ALS is maintained as physical function declines

AU - Robbins, R. A.

AU - Simmons, Zachary

AU - Bremer, B. A.

AU - Walsh, S. M.

AU - Fischer, S.

PY - 2001/2/27

Y1 - 2001/2/27

N2 - Objectives: To study patients with ALS to determine how physical function, quality of life (QOL), and spirituality or religiousness change over time, and what relationship these changes have to one another. Methods: Sixty patients with ALS were studied prospectively. They were assessed at baseline, 3 months, and 6 months, using questionnaires designed to measure general quality of life (McGill Quality of Life questionnaire), religiosity (Idler Index of Religiosity), ALS-specific health-related quality of life (SIP/ALS-19), and ALS-specific function (ALS functional rating scale). Results: A two-way repeated measures multivariate analysis of variance revealed that both the passage of time and the specific QOL scales used were factors in predicting patient quality of life (F[1, 59]= 9.87, p < 0.003 and F[3, 177]= 16.90, p < 0.001) Despite a progressive decline in physical function as measured by the ALS-specific function score, the genera] QOL and religiosity scores changed little. In contrast, the ALS-specific health-related QOL score declined in parallel with the ALS-specific function score. Conclusions: QOL in patients with ALS appears to be independent of physical function, which agrees with a previous cross-sectional study. The ALS-specific health-related QOL score is primarily a measure of physical function. QOL instruments that assess spiritual, religious, and psychological factors produce different results than those obtained using measures of physical function alone.

AB - Objectives: To study patients with ALS to determine how physical function, quality of life (QOL), and spirituality or religiousness change over time, and what relationship these changes have to one another. Methods: Sixty patients with ALS were studied prospectively. They were assessed at baseline, 3 months, and 6 months, using questionnaires designed to measure general quality of life (McGill Quality of Life questionnaire), religiosity (Idler Index of Religiosity), ALS-specific health-related quality of life (SIP/ALS-19), and ALS-specific function (ALS functional rating scale). Results: A two-way repeated measures multivariate analysis of variance revealed that both the passage of time and the specific QOL scales used were factors in predicting patient quality of life (F[1, 59]= 9.87, p < 0.003 and F[3, 177]= 16.90, p < 0.001) Despite a progressive decline in physical function as measured by the ALS-specific function score, the genera] QOL and religiosity scores changed little. In contrast, the ALS-specific health-related QOL score declined in parallel with the ALS-specific function score. Conclusions: QOL in patients with ALS appears to be independent of physical function, which agrees with a previous cross-sectional study. The ALS-specific health-related QOL score is primarily a measure of physical function. QOL instruments that assess spiritual, religious, and psychological factors produce different results than those obtained using measures of physical function alone.

UR - http://www.scopus.com/inward/record.url?scp=0035957088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035957088&partnerID=8YFLogxK

U2 - 10.1212/WNL.56.4.442

DO - 10.1212/WNL.56.4.442

M3 - Article

C2 - 11222784

AN - SCOPUS:0035957088

VL - 56

SP - 442

EP - 444

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 4

ER -