Quantification of intervertebral disc cartilaginous endplate morphology using MRI

E. E. Beattie, J. H. Yoder, S. M. Moon, E. J. Vresilovic, D. M. Elliott, A. C. Wright

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Introduction: The cartilaginous endplate (CEP) is a thin layer of hyaline cartilage which functions as a mechanical barrier between the nucleus pulposus and the vertebral endplate and as a gateway for nutrient transport to the intervertebral disc. To date, the geometry of the CEP has not been well defined. This study visualizes the three-dimensional morphology of the CEP and quantifies CEP thickness via a semi-automatic analysis technique. Methods: Human lumbar motion segments (n=24) were imaged using an optimized 3D FLASH sequence. MRI data were evaluated in the axial and mid-sagittal imaging planes for CEP area, circumference, anterior-posterior width, lateral width, and thickness. CEP thickness was evaluated at five anterior-posterior locations. Results: There was no significant difference in CEP circumference, area, A-P width, or lateral width with respect to superior/inferior location (p>0.7) or disc level (p>0.6) except between L1L2 and L4L5 (p<0.05) in which case L4L5 was significantly smaller in relative area. Mean CEP thickness across all disc levels and anterior-posterior locations was 0.50±0.20 mm. The CEP was found to be thinnest at the center of the disc. No correlation was found between CEP geometry and degeneration or age (p>0.5). Discussion: This study demonstrates the potential for MRI FLASH imaging coupled with automatic geometric quantification in evaluating the CEP as a potential contributor in the degenerative cascade.

Original languageEnglish (US)
Title of host publication2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Pages103-104
Number of pages2
DOIs
Publication statusPublished - Jun 29 2012
Event38th Annual Northeast Bioengineering Conference, NEBEC 2012 - Philadelphia, PA, United States
Duration: Mar 16 2012Mar 18 2012

Publication series

Name2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012

Other

Other38th Annual Northeast Bioengineering Conference, NEBEC 2012
CountryUnited States
CityPhiladelphia, PA
Period3/16/123/18/12

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All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Beattie, E. E., Yoder, J. H., Moon, S. M., Vresilovic, E. J., Elliott, D. M., & Wright, A. C. (2012). Quantification of intervertebral disc cartilaginous endplate morphology using MRI. In 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012 (pp. 103-104). [6206983] (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012). https://doi.org/10.1109/NEBC.2012.6206983