Quantification of intervertebral disc cartilaginous endplate morphology using MRI

E. E. Beattie, J. H. Yoder, S. M. Moon, E. J. Vresilovic, D. M. Elliott, A. C. Wright

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Introduction: The cartilaginous endplate (CEP) is a thin layer of hyaline cartilage which functions as a mechanical barrier between the nucleus pulposus and the vertebral endplate and as a gateway for nutrient transport to the intervertebral disc. To date, the geometry of the CEP has not been well defined. This study visualizes the three-dimensional morphology of the CEP and quantifies CEP thickness via a semi-automatic analysis technique. Methods: Human lumbar motion segments (n=24) were imaged using an optimized 3D FLASH sequence. MRI data were evaluated in the axial and mid-sagittal imaging planes for CEP area, circumference, anterior-posterior width, lateral width, and thickness. CEP thickness was evaluated at five anterior-posterior locations. Results: There was no significant difference in CEP circumference, area, A-P width, or lateral width with respect to superior/inferior location (p>0.7) or disc level (p>0.6) except between L1L2 and L4L5 (p<0.05) in which case L4L5 was significantly smaller in relative area. Mean CEP thickness across all disc levels and anterior-posterior locations was 0.50±0.20 mm. The CEP was found to be thinnest at the center of the disc. No correlation was found between CEP geometry and degeneration or age (p>0.5). Discussion: This study demonstrates the potential for MRI FLASH imaging coupled with automatic geometric quantification in evaluating the CEP as a potential contributor in the degenerative cascade.

Original languageEnglish (US)
Title of host publication2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Pages103-104
Number of pages2
DOIs
StatePublished - Jun 29 2012
Event38th Annual Northeast Bioengineering Conference, NEBEC 2012 - Philadelphia, PA, United States
Duration: Mar 16 2012Mar 18 2012

Publication series

Name2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012

Other

Other38th Annual Northeast Bioengineering Conference, NEBEC 2012
CountryUnited States
CityPhiladelphia, PA
Period3/16/123/18/12

Fingerprint

Magnetic resonance imaging
Imaging techniques
Cartilage
Nutrients
Geometry

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Beattie, E. E., Yoder, J. H., Moon, S. M., Vresilovic, E. J., Elliott, D. M., & Wright, A. C. (2012). Quantification of intervertebral disc cartilaginous endplate morphology using MRI. In 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012 (pp. 103-104). [6206983] (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012). https://doi.org/10.1109/NEBC.2012.6206983
Beattie, E. E. ; Yoder, J. H. ; Moon, S. M. ; Vresilovic, E. J. ; Elliott, D. M. ; Wright, A. C. / Quantification of intervertebral disc cartilaginous endplate morphology using MRI. 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012. 2012. pp. 103-104 (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012).
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Beattie, EE, Yoder, JH, Moon, SM, Vresilovic, EJ, Elliott, DM & Wright, AC 2012, Quantification of intervertebral disc cartilaginous endplate morphology using MRI. in 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012., 6206983, 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 103-104, 38th Annual Northeast Bioengineering Conference, NEBEC 2012, Philadelphia, PA, United States, 3/16/12. https://doi.org/10.1109/NEBC.2012.6206983

Quantification of intervertebral disc cartilaginous endplate morphology using MRI. / Beattie, E. E.; Yoder, J. H.; Moon, S. M.; Vresilovic, E. J.; Elliott, D. M.; Wright, A. C.

2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012. 2012. p. 103-104 6206983 (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Beattie EE, Yoder JH, Moon SM, Vresilovic EJ, Elliott DM, Wright AC. Quantification of intervertebral disc cartilaginous endplate morphology using MRI. In 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012. 2012. p. 103-104. 6206983. (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012). https://doi.org/10.1109/NEBC.2012.6206983