Quantifying the effect of isoflurane and nitrous oxide on somatosensory-evoked potentials

Usha Devadoss, S. Babu, V. T. Cherian

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Anaesthetic techniques may have a significant effect on intraoperative-evoked potentials (EP). The present study is designed to compare propofol anaesthesia with Isoflurane (with or without nitrous oxide) during intraoperative somatosensory-evoked potential (SSEP) monitoring in 15 ASA Grade I and II patients undergoing surgery for intracranial tumours. SSEPs in response to median and posterior tibial nerve stimulation were recorded under four different anaesthetic conditions: 1) Propofol infusion and ventilation with air-oxygen, 2) Isoflurane, 1.0 MAC and ventilation with air-oxygen, 3) Isoflurane 1.0 MAC and ventilation with nitrous oxide-oxygen, and 4) Return to Isoflurane, 1.0 MAC and ventilation with air-oxygen. Intraoperative monitoring of somatosensory evoked potentials is best recordable using propofol. The morphology of the EP is reproducible with Isoflurane. This effect is exaggerated when it is advisable to avoid nitrous oxide.

Original languageEnglish (US)
Pages (from-to)40-44
Number of pages5
JournalIndian Journal of Anaesthesia
Volume54
Issue number1
DOIs
StatePublished - Jan 2010

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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