Quantitative analysis of creatinine in urine by metalized nanostructured parylene

Hui Wang, Niranjan Malvadkar, S. Koytek, J. Bylander, W. Brian Reeves, Melik C. Demirel

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A highly accurate, real-time multisensor agent monitor for biomarker detection is required for early detection of kidney diseases. Urine creatinine level can provide useful information on the status of the kidney. We prepare nanostructured surface-enhanced Raman spectroscopy (SERS) substrates without template or lithography, which provides controllable, well-organized nanostructures on the surface, for the quantitative analysis of creatinine concentration in urine. We present our work on sensitivity of the SERS substrate to urine samples collected from diabetic patients and healthy persons. We report the preparation of a new type of SERS substrate, which provides fast (<10s), highly sensitive (creatinine concentration <0.5 μg/mL) and reproducible (<5% variation) detection of urine. Our method to analyze the creatinine level in urine is in good agreement with the enzymatic method.

Original languageEnglish (US)
Article number027004
JournalJournal of Biomedical Optics
Volume15
Issue number2
DOIs
StatePublished - Dec 1 2010

Fingerprint

creatinine
urine
quantitative analysis
Creatinine
Raman spectroscopy
Chemical analysis
Substrates
kidney diseases
Biomarkers
Lithography
biomarkers
kidneys
Nanostructures
monitors
templates
lithography
parylene
preparation
sensitivity

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Wang, Hui ; Malvadkar, Niranjan ; Koytek, S. ; Bylander, J. ; Reeves, W. Brian ; Demirel, Melik C. / Quantitative analysis of creatinine in urine by metalized nanostructured parylene. In: Journal of Biomedical Optics. 2010 ; Vol. 15, No. 2.
@article{0d4cbadfae2c46c1843ed1c7440d3475,
title = "Quantitative analysis of creatinine in urine by metalized nanostructured parylene",
abstract = "A highly accurate, real-time multisensor agent monitor for biomarker detection is required for early detection of kidney diseases. Urine creatinine level can provide useful information on the status of the kidney. We prepare nanostructured surface-enhanced Raman spectroscopy (SERS) substrates without template or lithography, which provides controllable, well-organized nanostructures on the surface, for the quantitative analysis of creatinine concentration in urine. We present our work on sensitivity of the SERS substrate to urine samples collected from diabetic patients and healthy persons. We report the preparation of a new type of SERS substrate, which provides fast (<10s), highly sensitive (creatinine concentration <0.5 μg/mL) and reproducible (<5{\%} variation) detection of urine. Our method to analyze the creatinine level in urine is in good agreement with the enzymatic method.",
author = "Hui Wang and Niranjan Malvadkar and S. Koytek and J. Bylander and Reeves, {W. Brian} and Demirel, {Melik C.}",
year = "2010",
month = "12",
day = "1",
doi = "10.1117/1.3369002",
language = "English (US)",
volume = "15",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "SPIE",
number = "2",

}

Quantitative analysis of creatinine in urine by metalized nanostructured parylene. / Wang, Hui; Malvadkar, Niranjan; Koytek, S.; Bylander, J.; Reeves, W. Brian; Demirel, Melik C.

In: Journal of Biomedical Optics, Vol. 15, No. 2, 027004, 01.12.2010.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Quantitative analysis of creatinine in urine by metalized nanostructured parylene

AU - Wang, Hui

AU - Malvadkar, Niranjan

AU - Koytek, S.

AU - Bylander, J.

AU - Reeves, W. Brian

AU - Demirel, Melik C.

PY - 2010/12/1

Y1 - 2010/12/1

N2 - A highly accurate, real-time multisensor agent monitor for biomarker detection is required for early detection of kidney diseases. Urine creatinine level can provide useful information on the status of the kidney. We prepare nanostructured surface-enhanced Raman spectroscopy (SERS) substrates without template or lithography, which provides controllable, well-organized nanostructures on the surface, for the quantitative analysis of creatinine concentration in urine. We present our work on sensitivity of the SERS substrate to urine samples collected from diabetic patients and healthy persons. We report the preparation of a new type of SERS substrate, which provides fast (<10s), highly sensitive (creatinine concentration <0.5 μg/mL) and reproducible (<5% variation) detection of urine. Our method to analyze the creatinine level in urine is in good agreement with the enzymatic method.

AB - A highly accurate, real-time multisensor agent monitor for biomarker detection is required for early detection of kidney diseases. Urine creatinine level can provide useful information on the status of the kidney. We prepare nanostructured surface-enhanced Raman spectroscopy (SERS) substrates without template or lithography, which provides controllable, well-organized nanostructures on the surface, for the quantitative analysis of creatinine concentration in urine. We present our work on sensitivity of the SERS substrate to urine samples collected from diabetic patients and healthy persons. We report the preparation of a new type of SERS substrate, which provides fast (<10s), highly sensitive (creatinine concentration <0.5 μg/mL) and reproducible (<5% variation) detection of urine. Our method to analyze the creatinine level in urine is in good agreement with the enzymatic method.

UR - http://www.scopus.com/inward/record.url?scp=77956624130&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956624130&partnerID=8YFLogxK

U2 - 10.1117/1.3369002

DO - 10.1117/1.3369002

M3 - Article

C2 - 20459278

AN - SCOPUS:77956624130

VL - 15

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 2

M1 - 027004

ER -