Quantitative genetics of traits associated with hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers with unaffected Greyhounds

Stuart Bliss, Rory J. Todhunter, Richard Quaas, George Casella, Rongling Wu, George Lust, Alma Jo Williams, Samuel Hamilton, Nathan L. Dykes, Amy Yeager, Robert O. Gilbert, Nancy I. Burton-Wurster, Gregory M. Acland

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective-To determine the genetic influence on expression of traits associated with canine hip dysplasia. Animals-193 dogs from an experimental canine pedigree. Procedure-An experimental canine pedigree was developed for linkage analysis of hip dysplasia by mating dysplastic Labrador Retrievers with nondysplastic Greyhounds. A statistical model was designed to test the effects of Labrador Retriever and Greyhound alleles on age at detection of femoral capital epiphyseal ossification, 8-month distraction index, and 8-month dorsolateral subluxation score. Results-The additive effect was significant for age at detection of femoral capital epiphyseal ossification. Restricted maximum likelihood estimates (± SD) for this trait were 6.4 ± 1.95, 10.2 ± 2.0, 10.8 ± 3.1, 11.4 ± 2.1, and 13.6 ± 4.6 days of age for Greyhounds, Greyhound backcross dogs, F1 dogs, Labrador Retriever backcross dogs, and Labrador Retrievers, respectively. The additive effect was also significant for the distraction index. Estimates for this trait were 0.21 ± 0.07, 0.29 ± 0.15, 0.44 ± 0.12, 0.52 ± 0.18, and 0.6 ± 0.17 for the same groups, respectively. For the dorsolateral subluxation score, additive and dominance effects were significant. Estimates for this trait were 73.5 ± 4.1, 71.3 ± 6.5, 69.1 ± 6.0, 50.6 ± 12.9, and 48.4 ± 7.7%, respectively, for the same groups. Conclusions-In this canine pedigree, traits associated with canine hip dysplasia are heritable. Phenotypic differences exist among founder dogs of each breed and their crosses. This pedigree should be useful for identification of quantitative trait loci underlying the dysplastic phenotype.

Original languageEnglish (US)
Pages (from-to)1029-1035
Number of pages7
JournalAmerican Journal of Veterinary Research
Volume63
Issue number7
DOIs
StatePublished - Jan 1 2002

Fingerprint

canine hip dysplasia
Newfoundland and Labrador
Greyhound
Hip Dislocation
genetic traits
Labrador Retriever
quantitative genetics
Pedigree
pedigree
Canidae
Dogs
Canine Hip Dysplasia
dogs
Thigh
Osteogenesis
thighs
Economics
bone formation
additive effect
Likelihood Functions

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Bliss, Stuart ; Todhunter, Rory J. ; Quaas, Richard ; Casella, George ; Wu, Rongling ; Lust, George ; Williams, Alma Jo ; Hamilton, Samuel ; Dykes, Nathan L. ; Yeager, Amy ; Gilbert, Robert O. ; Burton-Wurster, Nancy I. ; Acland, Gregory M. / Quantitative genetics of traits associated with hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers with unaffected Greyhounds. In: American Journal of Veterinary Research. 2002 ; Vol. 63, No. 7. pp. 1029-1035.
@article{17720af3441a43b69e2ada8ee5e1e18e,
title = "Quantitative genetics of traits associated with hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers with unaffected Greyhounds",
abstract = "Objective-To determine the genetic influence on expression of traits associated with canine hip dysplasia. Animals-193 dogs from an experimental canine pedigree. Procedure-An experimental canine pedigree was developed for linkage analysis of hip dysplasia by mating dysplastic Labrador Retrievers with nondysplastic Greyhounds. A statistical model was designed to test the effects of Labrador Retriever and Greyhound alleles on age at detection of femoral capital epiphyseal ossification, 8-month distraction index, and 8-month dorsolateral subluxation score. Results-The additive effect was significant for age at detection of femoral capital epiphyseal ossification. Restricted maximum likelihood estimates (± SD) for this trait were 6.4 ± 1.95, 10.2 ± 2.0, 10.8 ± 3.1, 11.4 ± 2.1, and 13.6 ± 4.6 days of age for Greyhounds, Greyhound backcross dogs, F1 dogs, Labrador Retriever backcross dogs, and Labrador Retrievers, respectively. The additive effect was also significant for the distraction index. Estimates for this trait were 0.21 ± 0.07, 0.29 ± 0.15, 0.44 ± 0.12, 0.52 ± 0.18, and 0.6 ± 0.17 for the same groups, respectively. For the dorsolateral subluxation score, additive and dominance effects were significant. Estimates for this trait were 73.5 ± 4.1, 71.3 ± 6.5, 69.1 ± 6.0, 50.6 ± 12.9, and 48.4 ± 7.7{\%}, respectively, for the same groups. Conclusions-In this canine pedigree, traits associated with canine hip dysplasia are heritable. Phenotypic differences exist among founder dogs of each breed and their crosses. This pedigree should be useful for identification of quantitative trait loci underlying the dysplastic phenotype.",
author = "Stuart Bliss and Todhunter, {Rory J.} and Richard Quaas and George Casella and Rongling Wu and George Lust and Williams, {Alma Jo} and Samuel Hamilton and Dykes, {Nathan L.} and Amy Yeager and Gilbert, {Robert O.} and Burton-Wurster, {Nancy I.} and Acland, {Gregory M.}",
year = "2002",
month = "1",
day = "1",
doi = "10.2460/ajvr.2002.63.1029",
language = "English (US)",
volume = "63",
pages = "1029--1035",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",
publisher = "American Veterinary Medical Association",
number = "7",

}

Bliss, S, Todhunter, RJ, Quaas, R, Casella, G, Wu, R, Lust, G, Williams, AJ, Hamilton, S, Dykes, NL, Yeager, A, Gilbert, RO, Burton-Wurster, NI & Acland, GM 2002, 'Quantitative genetics of traits associated with hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers with unaffected Greyhounds', American Journal of Veterinary Research, vol. 63, no. 7, pp. 1029-1035. https://doi.org/10.2460/ajvr.2002.63.1029

Quantitative genetics of traits associated with hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers with unaffected Greyhounds. / Bliss, Stuart; Todhunter, Rory J.; Quaas, Richard; Casella, George; Wu, Rongling; Lust, George; Williams, Alma Jo; Hamilton, Samuel; Dykes, Nathan L.; Yeager, Amy; Gilbert, Robert O.; Burton-Wurster, Nancy I.; Acland, Gregory M.

In: American Journal of Veterinary Research, Vol. 63, No. 7, 01.01.2002, p. 1029-1035.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Quantitative genetics of traits associated with hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers with unaffected Greyhounds

AU - Bliss, Stuart

AU - Todhunter, Rory J.

AU - Quaas, Richard

AU - Casella, George

AU - Wu, Rongling

AU - Lust, George

AU - Williams, Alma Jo

AU - Hamilton, Samuel

AU - Dykes, Nathan L.

AU - Yeager, Amy

AU - Gilbert, Robert O.

AU - Burton-Wurster, Nancy I.

AU - Acland, Gregory M.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Objective-To determine the genetic influence on expression of traits associated with canine hip dysplasia. Animals-193 dogs from an experimental canine pedigree. Procedure-An experimental canine pedigree was developed for linkage analysis of hip dysplasia by mating dysplastic Labrador Retrievers with nondysplastic Greyhounds. A statistical model was designed to test the effects of Labrador Retriever and Greyhound alleles on age at detection of femoral capital epiphyseal ossification, 8-month distraction index, and 8-month dorsolateral subluxation score. Results-The additive effect was significant for age at detection of femoral capital epiphyseal ossification. Restricted maximum likelihood estimates (± SD) for this trait were 6.4 ± 1.95, 10.2 ± 2.0, 10.8 ± 3.1, 11.4 ± 2.1, and 13.6 ± 4.6 days of age for Greyhounds, Greyhound backcross dogs, F1 dogs, Labrador Retriever backcross dogs, and Labrador Retrievers, respectively. The additive effect was also significant for the distraction index. Estimates for this trait were 0.21 ± 0.07, 0.29 ± 0.15, 0.44 ± 0.12, 0.52 ± 0.18, and 0.6 ± 0.17 for the same groups, respectively. For the dorsolateral subluxation score, additive and dominance effects were significant. Estimates for this trait were 73.5 ± 4.1, 71.3 ± 6.5, 69.1 ± 6.0, 50.6 ± 12.9, and 48.4 ± 7.7%, respectively, for the same groups. Conclusions-In this canine pedigree, traits associated with canine hip dysplasia are heritable. Phenotypic differences exist among founder dogs of each breed and their crosses. This pedigree should be useful for identification of quantitative trait loci underlying the dysplastic phenotype.

AB - Objective-To determine the genetic influence on expression of traits associated with canine hip dysplasia. Animals-193 dogs from an experimental canine pedigree. Procedure-An experimental canine pedigree was developed for linkage analysis of hip dysplasia by mating dysplastic Labrador Retrievers with nondysplastic Greyhounds. A statistical model was designed to test the effects of Labrador Retriever and Greyhound alleles on age at detection of femoral capital epiphyseal ossification, 8-month distraction index, and 8-month dorsolateral subluxation score. Results-The additive effect was significant for age at detection of femoral capital epiphyseal ossification. Restricted maximum likelihood estimates (± SD) for this trait were 6.4 ± 1.95, 10.2 ± 2.0, 10.8 ± 3.1, 11.4 ± 2.1, and 13.6 ± 4.6 days of age for Greyhounds, Greyhound backcross dogs, F1 dogs, Labrador Retriever backcross dogs, and Labrador Retrievers, respectively. The additive effect was also significant for the distraction index. Estimates for this trait were 0.21 ± 0.07, 0.29 ± 0.15, 0.44 ± 0.12, 0.52 ± 0.18, and 0.6 ± 0.17 for the same groups, respectively. For the dorsolateral subluxation score, additive and dominance effects were significant. Estimates for this trait were 73.5 ± 4.1, 71.3 ± 6.5, 69.1 ± 6.0, 50.6 ± 12.9, and 48.4 ± 7.7%, respectively, for the same groups. Conclusions-In this canine pedigree, traits associated with canine hip dysplasia are heritable. Phenotypic differences exist among founder dogs of each breed and their crosses. This pedigree should be useful for identification of quantitative trait loci underlying the dysplastic phenotype.

UR - http://www.scopus.com/inward/record.url?scp=0035985521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035985521&partnerID=8YFLogxK

U2 - 10.2460/ajvr.2002.63.1029

DO - 10.2460/ajvr.2002.63.1029

M3 - Article

C2 - 12118665

AN - SCOPUS:0035985521

VL - 63

SP - 1029

EP - 1035

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 7

ER -