Quantitative methods and bayesian models for flow cytometry analysis in HIV/AIDS research

Lin Lin, Cliburn Chan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Flow cytometry is a multiparameter single-cell assay ubiquitous in HIV/AIDS clinical and research settings for evaluating the immune response to the virus, therapy, and vaccination. In clinical practice, flow cytometry is used to monitor the CD4 and CD8 T cell counts of HIV-infected subjects. In research settings, flow cytometry is used to evaluate innate and antigen-specific responses to the HIV virus, so as to better understand pathogenesis, the mechanisms responsible for long-term nonprogression, and to develop effective immune-based interventions. In vaccine development, there is significant interest in the potential of flow-based biomarkers that can serve as surrogate measures of efficacy.

Original languageEnglish (US)
Title of host publicationQuantitative Methods for HIV/AIDS Research
PublisherCRC Press
Pages135-156
Number of pages22
ISBN (Electronic)9781498734257
ISBN (Print)9781498734233
DOIs
StatePublished - Jan 1 2017

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Flow Cytometry
Bayes Theorem
Bayesian Model
Acquired Immunodeficiency Syndrome
HIV
Virus
Research
Viruses
Vaccination
Vaccine
Immune Response
Biomarkers
T-cells
Therapy
Efficacy
Count
Monitor
Vaccines
Cell Count
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Mathematics(all)
  • Medicine(all)

Cite this

Lin, L., & Chan, C. (2017). Quantitative methods and bayesian models for flow cytometry analysis in HIV/AIDS research. In Quantitative Methods for HIV/AIDS Research (pp. 135-156). CRC Press. https://doi.org/10.1201/9781315120805
Lin, Lin ; Chan, Cliburn. / Quantitative methods and bayesian models for flow cytometry analysis in HIV/AIDS research. Quantitative Methods for HIV/AIDS Research. CRC Press, 2017. pp. 135-156
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Lin, L & Chan, C 2017, Quantitative methods and bayesian models for flow cytometry analysis in HIV/AIDS research. in Quantitative Methods for HIV/AIDS Research. CRC Press, pp. 135-156. https://doi.org/10.1201/9781315120805

Quantitative methods and bayesian models for flow cytometry analysis in HIV/AIDS research. / Lin, Lin; Chan, Cliburn.

Quantitative Methods for HIV/AIDS Research. CRC Press, 2017. p. 135-156.

Research output: Chapter in Book/Report/Conference proceedingChapter

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