Quantitative methods and bayesian models for flow cytometry analysis in HIV/AIDS research

Lin Lin, Cliburn Chan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Flow cytometry is a multiparameter single-cell assay ubiquitous in HIV/AIDS clinical and research settings for evaluating the immune response to the virus, therapy, and vaccination. In clinical practice, flow cytometry is used to monitor the CD4 and CD8 T cell counts of HIV-infected subjects. In research settings, flow cytometry is used to evaluate innate and antigen-specific responses to the HIV virus, so as to better understand pathogenesis, the mechanisms responsible for long-term nonprogression, and to develop effective immune-based interventions. In vaccine development, there is significant interest in the potential of flow-based biomarkers that can serve as surrogate measures of efficacy.

Original languageEnglish (US)
Title of host publicationQuantitative Methods for HIV/AIDS Research
PublisherCRC Press
Pages135-156
Number of pages22
ISBN (Electronic)9781498734257
ISBN (Print)9781498734233
DOIs
StatePublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • Mathematics(all)
  • Medicine(all)

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  • Cite this

    Lin, L., & Chan, C. (2017). Quantitative methods and bayesian models for flow cytometry analysis in HIV/AIDS research. In Quantitative Methods for HIV/AIDS Research (pp. 135-156). CRC Press. https://doi.org/10.1201/9781315120805