Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster

Gisele Passador-Gurgel, Wen Ping Hsieh, Priscilla Hunt, Nigel Deighton, Greg Gibson

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Although most genetic association studies are performed with the intention of detecting nucleotide polymorphisms that are correlated with a complex trait, transcript abundance should also be expected to associate with diseases or phenotypes. We performed a scan for such quantitative trait transcripts in adult female heads of the fruit fly (Drosophila melanogaster) that might explain variation for nicotine resistance. The strongest association was seen for abundance of ornithine aminotransferase transcripts, implicating detoxification and neurotransmitter biosynthesis as mediators of the quantitative response to the drug. Subsequently, genetic analysis and metabolite profiling confirmed a complex role for ornithine and GABA levels in modification of survival time upon chronic nicotine exposure. Differences between populations from North Carolina and California suggest that the resistance mechanism may be an evolved response to environmental exposure.

Original languageEnglish (US)
Pages (from-to)264-268
Number of pages5
JournalNature Genetics
Volume39
Issue number2
DOIs
StatePublished - Feb 1 2007

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Drosophila melanogaster
Nicotine
Ornithine-Oxo-Acid Transaminase
Ornithine
Environmental Exposure
Genetic Association Studies
Diptera
gamma-Aminobutyric Acid
Neurotransmitter Agents
Fruit
Nucleotides
Phenotype
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Passador-Gurgel, Gisele ; Hsieh, Wen Ping ; Hunt, Priscilla ; Deighton, Nigel ; Gibson, Greg. / Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster. In: Nature Genetics. 2007 ; Vol. 39, No. 2. pp. 264-268.
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Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster. / Passador-Gurgel, Gisele; Hsieh, Wen Ping; Hunt, Priscilla; Deighton, Nigel; Gibson, Greg.

In: Nature Genetics, Vol. 39, No. 2, 01.02.2007, p. 264-268.

Research output: Contribution to journalArticle

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