Quantity of residual thrombus after successful catheter-directed thrombolysis for Iliofemoral deep venous thrombosis correlates with recurrence

Faisal Aziz, A. J. Comerota

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objectives: Iliofemoral deep venous thrombosis (IFDVT) is an independent risk factor for recurrent DVT. It has been observed that recurrent DVT correlates with residual thrombus. This study evaluates whether risk of recurrence is related to the amount of residual thrombus following catheter-directed thrombolysis (CDT) for IFDVT. Methods: Patients who underwent CDT for IFDVT had their degree of lysis quantified by a reader blind to the patients' long-term clinical outcome. Patients were classified into two groups, ≥50% and <50% residual thrombus. Recurrence was defined as a symptomatic presentation with image verification of new or additional thrombus. Results: A total of 75 patients underwent CDT for IFDVT. Median follow-up was 35.9 months. Sixty-eight patients (91%) had no evidence of recurrence and seven (9%) developed recurrence. Of the patients who had ≥50% (mean 80%) residual thrombus, 50% (4/8) experienced recurrence, but in those with <50% (mean 35%) residual thrombus, only 5% (3/67) had recurrent DVT (P = 0.0014). Conclusion: The burden of residual thrombus at completion of CDT correlates with the risk of DVT recurrence. Patients having CDT for IFDVT had a lower risk of recurrence than expected. Successful clearing of acute clot in IFDVT patients significantly reduces the recurrence risk compared to patients with a large residual thrombus burden.

Original languageEnglish (US)
Pages (from-to)210-213
Number of pages4
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume44
Issue number2
DOIs
StatePublished - Aug 1 2012

Fingerprint

Venous Thrombosis
Thrombosis
Catheters
Recurrence

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

@article{8f377b9e1d034a0ea278572a3d7cf3cd,
title = "Quantity of residual thrombus after successful catheter-directed thrombolysis for Iliofemoral deep venous thrombosis correlates with recurrence",
abstract = "Objectives: Iliofemoral deep venous thrombosis (IFDVT) is an independent risk factor for recurrent DVT. It has been observed that recurrent DVT correlates with residual thrombus. This study evaluates whether risk of recurrence is related to the amount of residual thrombus following catheter-directed thrombolysis (CDT) for IFDVT. Methods: Patients who underwent CDT for IFDVT had their degree of lysis quantified by a reader blind to the patients' long-term clinical outcome. Patients were classified into two groups, ≥50{\%} and <50{\%} residual thrombus. Recurrence was defined as a symptomatic presentation with image verification of new or additional thrombus. Results: A total of 75 patients underwent CDT for IFDVT. Median follow-up was 35.9 months. Sixty-eight patients (91{\%}) had no evidence of recurrence and seven (9{\%}) developed recurrence. Of the patients who had ≥50{\%} (mean 80{\%}) residual thrombus, 50{\%} (4/8) experienced recurrence, but in those with <50{\%} (mean 35{\%}) residual thrombus, only 5{\%} (3/67) had recurrent DVT (P = 0.0014). Conclusion: The burden of residual thrombus at completion of CDT correlates with the risk of DVT recurrence. Patients having CDT for IFDVT had a lower risk of recurrence than expected. Successful clearing of acute clot in IFDVT patients significantly reduces the recurrence risk compared to patients with a large residual thrombus burden.",
author = "Faisal Aziz and Comerota, {A. J.}",
year = "2012",
month = "8",
day = "1",
doi = "10.1016/j.ejvs.2012.04.016",
language = "English (US)",
volume = "44",
pages = "210--213",
journal = "European Journal of Vascular and Endovascular Surgery",
issn = "1078-5884",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Quantity of residual thrombus after successful catheter-directed thrombolysis for Iliofemoral deep venous thrombosis correlates with recurrence

AU - Aziz, Faisal

AU - Comerota, A. J.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Objectives: Iliofemoral deep venous thrombosis (IFDVT) is an independent risk factor for recurrent DVT. It has been observed that recurrent DVT correlates with residual thrombus. This study evaluates whether risk of recurrence is related to the amount of residual thrombus following catheter-directed thrombolysis (CDT) for IFDVT. Methods: Patients who underwent CDT for IFDVT had their degree of lysis quantified by a reader blind to the patients' long-term clinical outcome. Patients were classified into two groups, ≥50% and <50% residual thrombus. Recurrence was defined as a symptomatic presentation with image verification of new or additional thrombus. Results: A total of 75 patients underwent CDT for IFDVT. Median follow-up was 35.9 months. Sixty-eight patients (91%) had no evidence of recurrence and seven (9%) developed recurrence. Of the patients who had ≥50% (mean 80%) residual thrombus, 50% (4/8) experienced recurrence, but in those with <50% (mean 35%) residual thrombus, only 5% (3/67) had recurrent DVT (P = 0.0014). Conclusion: The burden of residual thrombus at completion of CDT correlates with the risk of DVT recurrence. Patients having CDT for IFDVT had a lower risk of recurrence than expected. Successful clearing of acute clot in IFDVT patients significantly reduces the recurrence risk compared to patients with a large residual thrombus burden.

AB - Objectives: Iliofemoral deep venous thrombosis (IFDVT) is an independent risk factor for recurrent DVT. It has been observed that recurrent DVT correlates with residual thrombus. This study evaluates whether risk of recurrence is related to the amount of residual thrombus following catheter-directed thrombolysis (CDT) for IFDVT. Methods: Patients who underwent CDT for IFDVT had their degree of lysis quantified by a reader blind to the patients' long-term clinical outcome. Patients were classified into two groups, ≥50% and <50% residual thrombus. Recurrence was defined as a symptomatic presentation with image verification of new or additional thrombus. Results: A total of 75 patients underwent CDT for IFDVT. Median follow-up was 35.9 months. Sixty-eight patients (91%) had no evidence of recurrence and seven (9%) developed recurrence. Of the patients who had ≥50% (mean 80%) residual thrombus, 50% (4/8) experienced recurrence, but in those with <50% (mean 35%) residual thrombus, only 5% (3/67) had recurrent DVT (P = 0.0014). Conclusion: The burden of residual thrombus at completion of CDT correlates with the risk of DVT recurrence. Patients having CDT for IFDVT had a lower risk of recurrence than expected. Successful clearing of acute clot in IFDVT patients significantly reduces the recurrence risk compared to patients with a large residual thrombus burden.

UR - http://www.scopus.com/inward/record.url?scp=84864700615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864700615&partnerID=8YFLogxK

U2 - 10.1016/j.ejvs.2012.04.016

DO - 10.1016/j.ejvs.2012.04.016

M3 - Article

VL - 44

SP - 210

EP - 213

JO - European Journal of Vascular and Endovascular Surgery

JF - European Journal of Vascular and Endovascular Surgery

SN - 1078-5884

IS - 2

ER -