Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium

Leah B. Casabianca, David An, Jayakumar K. Natarajan, John N. Alumasa, Paul D. Roepe, Christian Wolf, Angel C. De Dios

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Abstract

Nuclear magnetic resonance (NMR) measurements of magnetic susceptibility have been utilized to study the equilibrium between two forms (high-spin monomer vs the antiferromagnetically coupled μ-oxo dimer) of ferriprotoporphyrin(IX) as a function of pH. The pH dependence of this equilibrium is significantly altered by the addition of either chloroquine or quinine. Chloroquine promotes the μ-oxo dimer whereas quinine promotes the monomer.

Original languageEnglish (US)
Pages (from-to)6077-6081
Number of pages5
JournalInorganic chemistry
Volume47
Issue number13
DOIs
StatePublished - Jul 7 2008

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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    Casabianca, L. B., An, D., Natarajan, J. K., Alumasa, J. N., Roepe, P. D., Wolf, C., & De Dios, A. C. (2008). Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium. Inorganic chemistry, 47(13), 6077-6081. https://doi.org/10.1021/ic800440d