Quorum sensing-disrupting brominated furanones protect the gnotobiotic brine shrimp Artemia franciscana from pathogenic Vibrio harveyi, Vibrio campbellii, and Vibrio parahaemolyticus isolates

Tom Defoirdt, Roselien Crab, Thomas K. Wood, Patrick Sorgeloos, Willy Verstraete, Peter Bossier

Research output: Contribution to journalArticle

122 Scopus citations


Autoinducer 2 (AI-2) quorum sensing was shown before to regulate the virulence of Vibrio harveyi towards the brine shrimp Artemia franciscana. In this study, several different pathogenic V. harveyi, Vibrio campbellii, and Vibrio parahaemolyticus isolates were shown to produce AI-2. Furthermore, disruption of AI-2 quorum sensing by a natural and a synthetic brominated furanone protected gnotobiotic Artemia from the pathogenic isolates in in vivo challenge tests.

Original languageEnglish (US)
Pages (from-to)6419-6423
Number of pages5
JournalApplied and environmental microbiology
Issue number9
Publication statusPublished - Sep 1 2006


All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

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