Rabbit aortic endothelial and medial histamine synthesis following short-term cholesterol feeding

Ronald A. Markle, Theodore M. Hollis

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Endothelial cells from thoracic aortas of pair-fed male Dutch belted rabbits maintained on a 0.5% cholesterol diet for 2 weeks were isolated by inverted lumenal surface trypsin washing. Mean endothelial histamine-forming capacities (HFC) of control and experimental groups were 718 ± 84 and 982 ± 109 dpm/mgm protein, respectively, while corresponding mean medial HFCs were 106 ± 10 and 93 ± 3 dpm/mgm protein. Determination of total serum cholesterol and histological examination of aortas indicate the experimental rabbits were in a hypercholesteremic, preatherosclerotic state. These results indicate that an atherogenic stress promotes increased endothelial histamine synthesis.

Original languageEnglish (US)
Pages (from-to)417-425
Number of pages9
JournalExperimental and Molecular Pathology
Volume23
Issue number3
DOIs
StatePublished - Dec 1975

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Rabbit aortic endothelial and medial histamine synthesis following short-term cholesterol feeding'. Together they form a unique fingerprint.

  • Cite this