Rabbit genital tissue is susceptible to infection by rabbit oral papillomavirus: An animal model for a genital tissue-targeting papillomavirus

S. B. Harvey, N. M. Cladel, L. R. Budgeon, P. A. Welsh, J. W. Griffith, C. M. Lang, N. D. Christensen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Rabbit oral papillomavirus (ROPV) is a mucosatropic papillomavirus which naturally infects oral mucosal sites of domestic rabbits. In this study, we tested the hypothesis that rabbit genital mucosa is also susceptible to ROPV infection by using the athymic mouse xenograft system and adult immunocompetent rabbits. Subrenal xenografts of ROPV-infected rabbit vulvar and penile sheath tissues were strongly positive for ROPV infection by histologic, in situ hybridization, and Southern analyses. Direct inoculation of adult rabbit penises with infectious ROPV produced small raised lesions of approximately 1 by 1 by 1 mm that were ROPV positive by both in situ hybridization and Southern analyses and were also viral capsid antigen positive by immunohistological staining. Infection of rabbit genital tissues with ROPV may be a useful animal model for the study of genital tissue- targeting papillomaviruses.

Original languageEnglish (US)
Pages (from-to)5239-5244
Number of pages6
JournalJournal of virology
Volume72
Issue number6
StatePublished - May 25 1998

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Rabbit oral papillomavirus
Papillomaviridae
biological resistance
genitalia
Animal Models
animal models
rabbits
Rabbits
Infection
in situ hybridization
infection
Papillomavirus Infections
capsid
penis
Heterografts
tissues
In Situ Hybridization
lesions (animal)
mucosa
mouth

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Harvey, S. B. ; Cladel, N. M. ; Budgeon, L. R. ; Welsh, P. A. ; Griffith, J. W. ; Lang, C. M. ; Christensen, N. D. / Rabbit genital tissue is susceptible to infection by rabbit oral papillomavirus : An animal model for a genital tissue-targeting papillomavirus. In: Journal of virology. 1998 ; Vol. 72, No. 6. pp. 5239-5244.
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Rabbit genital tissue is susceptible to infection by rabbit oral papillomavirus : An animal model for a genital tissue-targeting papillomavirus. / Harvey, S. B.; Cladel, N. M.; Budgeon, L. R.; Welsh, P. A.; Griffith, J. W.; Lang, C. M.; Christensen, N. D.

In: Journal of virology, Vol. 72, No. 6, 25.05.1998, p. 5239-5244.

Research output: Contribution to journalArticle

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